🔗 Sputnik virophage

🔗 Viruses

Sputnik virophage (from Russian cпутник "satellite", Latin "virus" and Greek φάγειν phagein "to eat") is a subviral agent that reproduces in amoeba cells that are already infected by a certain helper virus; Sputnik uses the helper virus's machinery for reproduction and inhibits replication of the helper virus.

Viruses like Sputnik that depend on co-infection of the host cell by helper viruses are known as satellite viruses. At its discovery in a Paris water-cooling tower in 2008 Sputnik was the first known satellite virus that inhibited replication of its helper virus and thus acted as a parasite of that virus. In analogy to the term bacteriophage it was called a virophage. However, the usage of this term and the relationship between virophages and classical satellite viruses remain controversial.

Sputnik virophages were found infecting giant viruses of Mimiviridae group A. However, they are able to grow in amoebae infected by Mimiviridae of any of the groups A, B, and C.