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🔗 Pharmacology

Human anti-mouse antibody or human anti-murine antibody (HAMA) is an antibody found in humans which reacts to immunoglobins found in mice.

🔗 Medicine 🔗 Psychology 🔗 Sociology 🔗 Science 🔗 Academic Journals

The replication crisis (or replicability crisis or reproducibility crisis) is, as of 2020, an ongoing methodological crisis in which it has been found that many scientific studies are difficult or impossible to replicate or reproduce. The replication crisis affects the social sciences and medicine most severely. The crisis has long-standing roots; the phrase was coined in the early 2010s as part of a growing awareness of the problem. The replication crisis represents an important body of research in the field of metascience.

Because the reproducibility of experimental results is an essential part of the scientific method, the inability to replicate the studies of others has potentially grave consequences for many fields of science in which significant theories are grounded on unreproducible experimental work. The replication crisis has been particularly widely discussed in the field of psychology and in medicine, where a number of efforts have been made to re-investigate classic results, to determine both the reliability of the results, and, if found to be unreliable, the reasons for the failure of replication.

The Artificio de Juanelo ("Gianello's artifice") was the name of two devices built in Toledo in the 16th century by Juanelo Turriano. They were designed to supply the city with a source of readily available water by lifting it from the Tagus (Tajo) river to the Alcázar. Now in ruins, the precise details of the operation of the devices are unknown, but at the time they were considered engineering wonders.

🔗 Caves

Snottite, also snoticle, is a microbial mat of single-celled extremophilic bacteria which hang from the walls and ceilings of caves and are similar to small stalactites, but have the consistency of nasal mucus. In the Frasassi Caves in Italy, over 70% of cells in Snottite have been identified as Acidithiobacillus thiooxidans, with smaller populations including an archaeon in the uncultivated 'G-plasma' clade of Thermoplasmatales (>15%) and a bacterium in the Acidimicrobiaceae family (>5%).

The bacteria derive their energy from chemosynthesis of volcanic sulfur compounds including H₂S and warm-water solution dripping down from above, producing sulfuric acid. Because of this, their waste products are highly acidic (approaching pH=0), with similar properties to battery acid. Researchers at the University of Texas have suggested that this sulfuric acid may be a more significant cause of cave formation than the usual explanation offered of the carbonic acid formed from carbon dioxide dissolved in water.

Snottites were brought to attention by researchers Diana Northup and Penny Boston studying them (and other organisms) in a toxic sulfur cave called Cueva de Villa Luz (Cave of the Lighted House), in Tabasco, Mexico. Snottites were first discovered in this cave by Jim Pisarowicz in 1986, who also coined the term.

The BBC series Wonders of the Solar System saw Professor Brian Cox examining snottites and positing that if there is life on Mars, it may be similarly primitive and hidden beneath the surface of the Red Planet.

🔗 Chess

Los Alamos chess (or anti-clerical chess) is a chess variant played on a 6×6 board without bishops. This was the first chess-like game played by a computer program. This program was written at Los Alamos Scientific Laboratory by Paul Stein and Mark Wells for the MANIAC I computer in 1956. The reduction of the board size and the number of pieces from standard chess was due to the very limited capacity of computers at the time.

The program was very simple, containing only about 600 instructions. It was mostly a minimax tree search and could look four plies ahead. For scoring the board at the end of the four-ply lookahead, it estimates a score for material and a score for mobility, then adds them up. Pseudocode for the chess program is described in Figure 11.4 of Newell, 2019. In 1958, a revised version was written for MANIAC II for full 8×8 chess, though its pseudocode was never published. There is a record of a single game by it, circa November 1958 (Table 11.2 of Newell, 2019).

🔗 Computer science 🔗 Economics 🔗 Engineering

In multi-objective optimization, the Pareto front (also called Pareto frontier or Pareto curve) is the set of all Pareto efficient solutions. The concept is widely used in engineering.^{: 111–148} It allows the designer to restrict attention to the set of efficient choices, and to make tradeoffs within this set, rather than considering the full range of every parameter.^{: 63–65 : 399–412}

🔗 Internet 🔗 Internet culture 🔗 Comedy

A Request for Comments (RFC), in the context of Internet governance, is a type of publication from the Internet Engineering Task Force (IETF) and the Internet Society (ISOC), usually describing methods, behaviors, research, or innovations applicable to the working of the Internet and Internet-connected systems.

Almost every April Fools' Day (1 April) since 1989, the Internet RFC Editor has published one or more humorous Request for Comments (RFC) documents, following in the path blazed by the June 1973 RFC 527 called ARPAWOCKY, a parody of Lewis Carroll's nonsense poem "Jabberwocky". The following list also includes humorous RFCs published on other dates.

🔗 Greece 🔗 Guild of Copy Editors 🔗 Turkey 🔗 Christianity 🔗 Catholicism 🔗 Christianity/theology 🔗 Greece/Byzantine world 🔗 Christianity/Eastern Orthodoxy 🔗 Christianity/Oriental Orthodoxy 🔗 Christianity/Syriac Christianity 🔗 Christianity/Christian history

The First Council of Nicaea ( ny-SEE-ə; Ancient Greek: Σύνοδος τῆς Νικαίας, romanized: Sýnodos tês Nikaías) was a council of Christian bishops convened in the Bithynian city of Nicaea (now İznik, Turkey) by the Roman Emperor Constantine I. The Council of Nicaea met from May until the end of July 325.

This ecumenical council was the first of many efforts to attain consensus in the church through an assembly representing all Christendom. Hosius of Corduba may have presided over its deliberations. Its main accomplishments were settlement of the Christological issue of the divine nature of God the Son and his relationship to God the Father, the construction of the first part of the Nicene Creed, mandating uniform observance of the date of Easter, and promulgation of early canon law.

🔗 Military history 🔗 Military history/North American military history 🔗 Military history/United States military history 🔗 Military history/World War II 🔗 Graffiti

Kilroy was here is a meme that became popular during World War II, typically seen in graffiti. Its origin is debated, but the phrase and the distinctive accompanying doodle became associated with GIs in the 1940s: a bald-headed man (sometimes depicted as having a few hairs) with a prominent nose peeking over a wall with his fingers clutching the wall.

"Mr Chad" or just "Chad" was the version that became popular in the United Kingdom. The character of Chad may have been derived from a British cartoonist in 1938, possibly pre-dating "Kilroy was here". According to Dave Wilton, "Some time during the war, Chad and Kilroy met, and in the spirit of Allied unity merged, with the British drawing appearing over the American phrase." Other names for the character include Smoe, Clem, Flywheel, Private Snoops, Overby, Eugene the Jeep, Scabooch, and Sapo.

According to Charles Panati, "The outrageousness of the graffiti was not so much what it said, but where it turned up." It is not known if there was an actual person named Kilroy who inspired the graffiti, although there have been claims over the years.

🔗 Internet culture

Eternal September or the September that never ended is Usenet slang for a period beginning in September 1993, the month that Internet service provider America Online (AOL) began offering Usenet access to its many users, overwhelming the existing culture for online forums.

Before then, Usenet was largely restricted to colleges, universities, and other research institutions. Every September, many incoming students would acquire access to Usenet for the first time, taking time to become accustomed to Usenet's standards of conduct and "netiquette". After a month or so, these new users would either learn to comply with the networks' social norms or tire of using the service.

Whereas the regular September student influx would quickly settle down, the influx of new users from AOL did not end and Usenet's existing culture did not have the capacity to integrate the sheer number of new users. The influx was exacerbated by the aggressive direct mailing campaign by AOL Chief Marketing Officer Jan Brandt, which most notably involved distributing millions of floppy disks and CD-ROMs with free trials of AOL.

Since then the popularity of the Internet has led to a constant stream of new users. Hence, from the point of view of the early Usenet, the influx of new users in September 1993 never ended.

Dave Fischer appears to have coined the term in a January 1994 post to alt.folklore.computers: "It's moot now. September 1993 will go down in net history as the September that never ended."