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🔗 Physics 🔗 Philosophy 🔗 Philosophy/Philosophy of science 🔗 Philosophy/Metaphysics

In physics and cosmology, the mathematical universe hypothesis (MUH), also known as the ultimate ensemble theory, is a speculative "theory of everything" (TOE) proposed by cosmologist Max Tegmark.

🔗 Medicine

Pyrotherapy (artificial fever) is a method of treatment by raising the body temperature or sustaining an elevated body temperature using a fever. In general, the body temperature was maintained at 41 °C (105 °F). Many diseases were treated by this method in the first half of the 20th century. In general, it was done by exposing the patient to hot baths, warm air, or (electric) blankets. The technique reached its peak of sophistication in the early 20th century with malariotherapy, in which Plasmodium vivax, a causative agent of malaria, was allowed to infect already ill patients in order to produce intense fever for therapeutic ends. The sophistication of this approach lay in using effective anti-malarial drugs to control the P. vivax infection, while maintaining the fever it causes to the detriment of other, ongoing, and then-incurable infections present in the patient, such as late-stage syphilis. This type of pyrotherapy was most famously used by psychiatrist Julius Wagner-Jauregg, who won the Nobel Prize for Medicine in 1927 for his elaboration of the procedure in treating neurosyphilitics.

🔗 Mathematics 🔗 Economics 🔗 Game theory

A Vickrey auction or sealed-bid second-price auction (SBSPA) is a type of sealed-bid auction. Bidders submit written bids without knowing the bid of the other people in the auction. The highest bidder wins but the price paid is the second-highest bid. This type of auction is strategically similar to an English auction and gives bidders an incentive to bid their true value. The auction was first described academically by Columbia University professor William Vickrey in 1961 though it had been used by stamp collectors since 1893. In 1797 Johann Wolfgang von Goethe sold a manuscript using a sealed-bid, second-price auction.

Vickrey's original paper mainly considered auctions where only a single, indivisible good is being sold. The terms Vickrey auction and second-price sealed-bid auction are, in this case only, equivalent and used interchangeably. In the case of multiple identical goods, the bidders submit inverse demand curves and pay the opportunity cost.

Vickrey auctions are much studied in economic literature but uncommon in practice. Generalized variants of the Vickrey auction for multiunit auctions exist, such as the generalized second-price auction used in Google's and Yahoo!'s online advertisement programmes (not incentive compatible) and the Vickrey–Clarke–Groves auction (incentive compatible).

🔗 Skepticism 🔗 Neuroscience 🔗 Physiology

The gut–brain axis is the two-way biochemical signaling that takes place between the gastrointestinal tract (GI tract) and the central nervous system (CNS). The term "gut–brain axis" is occasionally used to refer to the role of the gut microbiota in the interplay as well. The "microbiota–gut–brain (MGB or BGM) axis" explicitly includes the role of gut microbiota in the biochemical signaling events that take place between the GI tract and the CNS. Broadly defined, the gut–brain axis includes the central nervous system, neuroendocrine system, neuroimmune systems, the hypothalamic–pituitary–adrenal axis (HPA axis), sympathetic and parasympathetic arms of the autonomic nervous system, the enteric nervous system, vagus nerve, and the gut microbiota.

Chemicals released in the gut by the microbiome can vastly influence the development of the brain, starting from birth. A review from 2015 states that the microbiome influences the central nervous system by “regulating brain chemistry and influencing neuro-endocrine systems associated with stress response, anxiety and memory function”. The gut, sometimes referred to as the “second brain”, functions off of the same type of neural network as the central nervous system, suggesting why it plays a significant role in brain function and mental health.

The bidirectional communication is done by immune, endocrine, humoral and neural connections between the gastrointestinal tract and the central nervous system. More research suggests that the gut microorganisms influence the function of the brain by releasing the following chemicals: cytokines, neurotransmitters, neuropeptides, chemokines, endocrine messengers and microbial metabolites such as "short-chain fatty acids, branched chain amino acids, and peptidoglycans”. The intestinal microbiome can then divert these products to the brain via the blood, neuropod cells, nerves, endocrine cells and more to be determined. The products then arrive at important locations in the brain, impacting different metabolic processes. Studies have confirmed communication between the hippocampus, the prefrontal cortex and the amygdala (responsible for emotions and motivation), which acts as a key node in the gut-brain behavioral axis.

While IBS is the only disease confirmed to be directly influenced by the gut microbiome, many disorders (such as anxiety, autism, depression and schizophrenia) have been linked to the gut-brain axis as well. The impact of the axis, and the various ways in which one can influence it, remains a promising research field which could result in future treatments for psychiatric, age-related, neurodegenerative and neurodevelopmental disorders. For example, according to a study from 2017, “probiotics have the ability to restore normal microbial balance, and therefore have a potential role in the treatment and prevention of anxiety and depression”.

The first of the brain–gut interactions shown, was the cephalic phase of digestion, in the release of gastric and pancreatic secretions in response to sensory signals, such as the smell and sight of food. This was first demonstrated by Pavlov through Nobel prize winning research in 1904.

Scientific interest in the field had already led to review in the second half of the 20th century. It was promoted further by a 2004 primary research study showing that germ-free (GF) mice showed an exaggerated HPA axis response to stress compared to non-GF laboratory mice.

As of October 2016, most of the work done on the role of gut microbiota in the gut–brain axis had been conducted in animals, or on characterizing the various neuroactive compounds that gut microbiota can produce. Studies with humans – measuring variations in gut microbiota between people with various psychiatric and neurological conditions or when stressed, or measuring effects of various probiotics (dubbed "psychobiotics" in this context) – had generally been small and were just beginning to be generalized. Whether changes to the gut microbiota are a result of disease, a cause of disease, or both in any number of possible feedback loops in the gut–brain axis, remained unclear.

🔗 Medicine 🔗 Medicine/Pulmonology 🔗 Plants 🔗 Horticulture and Gardening 🔗 Medicine/Society and Medicine

Botanical sexism is a term coined by horticulturist Tom Ogren to describe the planting of male plants instead of female plants of certain dioecious species including: willows, poplars, aspens, ashes, silver maples, pistache, mulberry, pepper tree and other woody plants such as junipers, yew pines, fern pines, wax myrtles, alpine currants, plum yews, and yews According to Ogren, pollen allergies have been amplified due to the planting in urban areas of male clones which increases the amount of pollen in the air. Male plants are commonly used in urban areas because plants with female flowers produce fruits and flowers that litter the landscape. The planting of more female plants would decrease the overall amount of pollen since they do not produce pollen and remove pollen from the air for pollination. The theory has existed since at least the 2000s. Biological sexism is used in the Ogren Plant Allergy Scale (OPALS), which has been adopted by the United States Department of Agriculture. Botanical sexism has found some scientific acceptance as a reason for increased allergies and asthma; however, other scientists have also been critical of it, stating that it only applies to certain trees and is not as widespread as Ogren alleges.

🔗 Physics

When using the term 'the speed of light' it is sometimes necessary to make the distinction between its one-way speed and its two-way speed. The "one-way" speed of light, from a source to a detector, cannot be measured independently of a convention as to how to synchronize the clocks at the source and the detector. What can however be experimentally measured is the round-trip speed (or "two-way" speed of light) from the source to a mirror (or other method of reflection) and back again to detector. Albert Einstein chose a synchronization convention (see Einstein synchronization) that made the one-way speed equal to the two-way speed. The constancy of the one-way speed in any given inertial frame is the basis of his special theory of relativity, although all experimentally verifiable predictions of this theory do not depend on that convention.

Experiments that attempt to directly probe the one-way speed of light independent of synchronization have been proposed, but none have succeeded in doing so. Those experiments directly establish that synchronization with slow clock-transport is equivalent to Einstein synchronization, which is an important feature of special relativity. However, those experiments cannot directly establish the isotropy of the one-way speed of light since it has been shown that slow clock-transport, the laws of motion, and the way inertial reference frames are defined already involve the assumption of isotropic one-way speeds and thus, are equally conventional. In general, it was shown that these experiments are consistent with anisotropic one-way light speed as long as the two-way light speed is isotropic.

The 'speed of light' in this article refers to the speed of all electromagnetic radiation in vacuum.

🔗 Fishes

The sturddlefish is a hybrid of the American paddlefish (Polyodon spathula) and the Russian sturgeon (Acipenser gueldenstaedtii), accidentally created by researchers in 2019 and announced in 2020. Obtaining living hybrids through breeding individuals from different families is unusual, especially given that the two species' last common ancestor lived 184 million years ago. The hybrids were created accidentally during attempts to induce gynogenesis, a type of parthenogenic reproduction where a sperm cell must be present to trigger embryogenesis but does not genetically contribute to the offspring. Hundreds of hybrid fish were created, of which about two-thirds survived over one month, and about 100 survived for one year. As of July 2020, all living hybrid fish are living in captivity at the research lab in Hungary. There are no further plans to create new sturddlefish.

🔗 Medicine 🔗 Medicine/Neurology 🔗 Epilepsy

Musicogenic seizure, also known as music-induced seizure, is a rare type of seizure, with an estimated prevalence of 1 in 10,000,000 individuals, that arises from disorganized or abnormal brain electrical activity when a person hears or is exposed to a specific type of sound or musical stimuli. There are challenges when diagnosing a music-induced seizure due to the broad scope of triggers, and time delay between a stimulus and seizure. In addition, the causes of musicogenic seizures are not well-established as solely limited cases and research have been discovered and conducted respectively. Nevertheless, the current understanding of the mechanism behind musicogenic seizure is that music triggers the part of the brain that is responsible for evoking an emotion associated with that music. Dysfunction in this system leads to an abnormal release of dopamine, eventually inducing seizure.

Currently, there are diverse intervention strategies that patients can choose from depending on their situations. They can have surgery to remove the region of the brain that generates a seizure. Behavioral therapy is also available; patients are trained to gain emotional control to reduce the frequency of seizure. Medications like carbamazepine and phenytoin (medication for general seizure) also suggest effectiveness to mitigate music-induced seizures.

🔗 Internet culture 🔗 Songs 🔗 Electronic music

"The Most Mysterious Song on the Internet" (also known as "Like the Wind", "Blind the Wind", "Check It In, Check It Out" or "Take It In, Take It Out" after lines in fan-interpreted lyrics; acronymed as TMMSOTI or TMS) is the nickname given to an unidentified song recording, most likely composed in the 1980s.

The song was reportedly recorded from a Norddeutscher Rundfunk (NDR) broadcast sometime in the mid-1980s, likely during or after 1984. Since 2019, this song has been the subject of a viral Internet phenomenon, with many users of sites such as Reddit and Discord involved in a collaborative effort to search for the origins of the song. Through the search, other unknown songs were discovered. Users have coined the term "Lostwave" to describe songs of this nature.

🔗 Computing

A lace card is a punched card with all holes punched (also called a whoopee card, ventilator card, flyswatter card, or IBM doily). They were mainly used as practical jokes to cause disruption in card readers. Card readers tended to jam when a lace card was inserted, as the resulting card had too little structural strength to avoid buckling inside the mechanism. Card punches could also jam trying to produce cards with all holes punched, owing to power-supply problems. When a lace card was fed through the reader, a card knife or card saw (a flat tool used with punched card readers and card punches) was needed to clear the jam.