Topic: Biology

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๐Ÿ”— Dallol

๐Ÿ”— Volcanoes ๐Ÿ”— Biology ๐Ÿ”— Africa ๐Ÿ”— Geology ๐Ÿ”— Ethiopia

Dallol is a unique, terrestrial hydrothermal system around a cinder cone volcano in the Danakil Depression, northeast of the Erta Ale Range in Ethiopia. It is known for its unearthly colors and mineral patterns, and the very acidic fluids that discharge from its hydrothermal springs.

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๐Ÿ”— Mirror life

๐Ÿ”— Biology ๐Ÿ”— Molecular and Cell Biology ๐Ÿ”— Chemistry ๐Ÿ”— Genetics

Mirror life (also called mirror-image life, chiral life, or enantiomeric life) is a hypothetical form of life with mirror-reflected molecular building blocks. The possibility of mirror life was first discussed by Louis Pasteur. Although this alternative life form has not been discovered in nature, efforts to build a mirror-image version of biology's molecular machinery are already underway.

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๐Ÿ”— Blue Field Entoptic Phenomenon

๐Ÿ”— Medicine ๐Ÿ”— Biology

The blue field entoptic phenomenon is an entoptic phenomenon characterized by the appearance of tiny bright dots (nicknamed blue-sky sprites) moving quickly along undulating pathways in the visual field, especially when looking into bright blue light such as the sky. The dots are short-lived, visible for about one second or less, and traveling short distances along seemingly random, undulating paths. Some of them seem to follow the same path as other dots before them. The dots may appear elongated along the path, like tiny worms. The dots' rate of travel appears to vary in synchrony with the heartbeat: they briefly accelerate at each beat. The dots appear in the central field of view, within 15 degrees from the fixation point. The left and right eye see different, seemingly random, dot patterns; a person viewing through both eyes sees a combination of both left and right visual field disturbances. While seeing the phenomenon, lightly pressing inward on the sides of the eyeballs at the lateral canthus causes the movement to stop being fluid and the dots to move only when the heart beats.

Most people are able to see this phenomenon in the sky, although it is relatively weak in most instances; many will not notice it until asked to pay attention. The dots are highly conspicuous against any monochromatic blue background of a wavelength of around 430ย nm in place of the sky. The phenomenon is also known as Scheerer's phenomenon, after the German ophthalmologist Richard Scheerer, who first drew clinical attention to it in 1924.

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๐Ÿ”— Belyayev's Fox Experiment

๐Ÿ”— Biography ๐Ÿ”— Soviet Union ๐Ÿ”— Russia ๐Ÿ”— Biology ๐Ÿ”— Biography/science and academia ๐Ÿ”— Russia/science and education in Russia ๐Ÿ”— Genetics ๐Ÿ”— Russia/physical geography of Russia

Dmitry Konstantinovich Belyayev (Russian: ะ”ะผะธฬั‚ั€ะธะน ะšะพะฝัั‚ะฐะฝั‚ะธฬะฝะพะฒะธั‡ ะ‘ะตะปัฬะตะฒ, 17 July 1917 โ€“ 14 November 1985) was a Russian geneticist and academician who served as director of the Institute of Cytology and Genetics (IC&G) of the USSR Academy of Sciences, Novosibirsk, from 1959 to 1985. His decades-long effort to breed domesticated foxes was described by The New York Times as โ€œarguably the most extraordinary breeding experiment ever conducted.โ€ A 2010 article in Scientific American stated that Belyayev โ€œmay be the man most responsible for our understanding of the process by which wolves were domesticated into our canine companions.โ€

Beginning in the 1950s, in order to uncover the genetic basis of the distinctive behavioral and physiological attributes of domesticated animals, Belyayev and his team spent decades breeding the wild silver fox (Vulpes vulpes) and selecting for reproduction only those individuals in each generation that showed the least fear of humans. After several generations of controlled breeding, a majority of the silver foxes no longer showed any fear of humans and often wagged their tails and licked their human caretakers to show affection. They also began to display spotted coats, floppy ears, curled tails, as well as other physical attributes often found in domesticated animals, thus confirming Belyayevโ€™s hypothesis that both the behavioral and physical traits of domesticated animals could be traced to "a collection of genes that conferred a propensity to tamenessโ€”a genotype that the foxes perhaps shared with any species that could be domesticated".

Belyayevโ€™s experiments were the result of a politically motivated demotion, in response to defying the now discredited non-Mendellian theories of Lysenkoism, which were politically accepted in the Soviet Union at the time. Belyayev has since been vindicated in recent years by major scientific journals, and by the Soviet establishment as a pioneering figure in modern genetics.

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๐Ÿ”— HeLa, the oldest and most commonly used human cell line

๐Ÿ”— Viruses ๐Ÿ”— Biology ๐Ÿ”— Philosophy ๐Ÿ”— Philosophy/Contemporary philosophy ๐Ÿ”— History of Science ๐Ÿ”— Molecular and Cell Biology ๐Ÿ”— Philosophy/Ethics ๐Ÿ”— Genetics ๐Ÿ”— Evolutionary biology ๐Ÿ”— Science Policy ๐Ÿ”— Molecular Biology/Molecular and Cell Biology

HeLa (; also Hela or hela) is an immortal cell line used in scientific research. It is the oldest and most commonly used human cell line. The line was derived from cervical cancer cells taken on February 8, 1951 from Henrietta Lacks, a patient who died of cancer on October 4, 1951. The cell line was found to be remarkably durable and prolific, which gives rise to its extensive use in scientific research.

The cells from Lacks's cancerous cervical tumor were taken without her knowledge or consent, which was common practice at the time. Cell biologist George Otto Gey found that they could be kept alive, and developed a cell line. Previously, cells cultured from other human cells would only survive for a few days. Scientists would spend more time trying to keep the cells alive than performing actual research on them. Cells from Lacks' tumor behaved differently. As was custom for Gey's lab assistant, she labeled the culture 'HeLa', the first two letters of the patient's first and last name; this became the name of the cell line.

These were the first human cells grown in a lab that were naturally "immortal", meaning that they do not die after a set number of cell divisions (i.e. cellular senescence). These cells could be used for conducting a multitude of medical experimentsโ€”if the cells died, they could simply be discarded and the experiment attempted again on fresh cells from the culture. This represented an enormous boon to medical and biological research, as previously stocks of living cells were limited and took significant effort to culture.

The stable growth of HeLa enabled a researcher at the University of Minnesota hospital to successfully grow polio virus, enabling the development of a vaccine, and by 1952, Jonas Salk developed a vaccine for polio using these cells. To test Salk's new vaccine, the cells were put into mass production in the first-ever cell production factory.

In 1953, HeLa cells were the first human cells successfully cloned and demand for the HeLa cells quickly grew in the nascent biomedical industry. Since the cells' first mass replications, they have been used by scientists in various types of investigations including disease research, gene mapping, effects of toxic substances on organisms, and radiation on humans. Additionally, HeLa cells have been used to test human sensitivity to tape, glue, cosmetics, and many other products.

Scientists have grown an estimated 50 million metricย tons of HeLa cells, and there are almost 11,000ย patents involving these cells.

The HeLa cell lines are also notorious for invading other cell cultures in laboratory settings. Some have estimated that HeLa cells have contaminated 10โ€“20% of all cell lines currently in use.

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๐Ÿ”— Panspermia

๐Ÿ”— Biology ๐Ÿ”— Skepticism ๐Ÿ”— Solar System

Panspermia (from Ancient Greek ฯ€แพถฮฝ (pan), meaning 'all', and ฯƒฯ€ฮญฯฮผฮฑ (sperma), meaning 'seed') is the hypothesis that life exists throughout the Universe, distributed by space dust, meteoroids, asteroids, comets, planetoids, and also by spacecraft carrying unintended contamination by microorganisms. Distribution may have occurred spanning galaxies, and so may not be restricted to the limited scale of solar systems.

Panspermia hypotheses propose (for example) that microscopic life-forms that can survive the effects of space (such as extremophiles) can become trapped in debris ejected into space after collisions between planets and small Solar System bodies that harbor life. Some organisms may travel dormant for an extended amount of time before colliding randomly with other planets or intermingling with protoplanetary disks. Under certain ideal impact circumstances (into a body of water, for example), and ideal conditions on a new planet's surfaces, it is possible that the surviving organisms could become active and begin to colonize their new environment. At least one report finds that endospores from a type of Bacillus bacteria found in Morocco can survive being heated to 420ย ยฐC (788ย ยฐF), making the argument for Panspermia even stronger. Panspermia studies concentrate not on how life began, but on methods that may distribute it in the Universe.

Pseudo-panspermia (sometimes called "soft panspermia" or "molecular panspermia") argues that the pre-biotic organic building-blocks of life originated in space, became incorporated in the solar nebula from which planets condensed, and were furtherโ€”and continuouslyโ€”distributed to planetary surfaces where life then emerged (abiogenesis). From the early 1970s, it started to become evident that interstellar dust included a large component of organic molecules. Interstellar molecules are formed by chemical reactions within very sparse interstellar or circumstellar clouds of dust and gas. The dust plays a critical role in shielding the molecules from the ionizing effect of ultraviolet radiation emitted by stars.

The chemistry leading to life may have begun shortly after the Big Bang, 13.8 billion years ago, during a habitable epoch when the Universe was only 10 to 17 million years old. Though the presence of life is confirmed only on the Earth, some scientists think that extraterrestrial life is not only plausible, but probable or inevitable. Probes and instruments have started examining other planets and moons in the Solar System and in other planetary systems for evidence of having once supported simple life, and projects such as SETI attempt to detect radio transmissions from possible extraterrestrial civilizations.

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๐Ÿ”— Hypothetical types of biochemistry

๐Ÿ”— Biology ๐Ÿ”— Science Fiction ๐Ÿ”— Chemistry

Hypothetical types of biochemistry are forms of biochemistry speculated to be scientifically viable but not proven to exist at this time. The kinds of living organisms currently known on Earth all use carbon compounds for basic structural and metabolic functions, water as a solvent, and DNA or RNA to define and control their form. If life exists on other planets or moons, it may be chemically similar; it is also possible that there are organisms with quite different chemistriesโ€”for instance, involving other classes of carbon compounds, compounds of another element, or another solvent in place of water.

The possibility of life-forms being based on "alternative" biochemistries is the topic of an ongoing scientific discussion, informed by what is known about extraterrestrial environments and about the chemical behaviour of various elements and compounds. It is of interest in synthetic biology and is also a common subject in science fiction.

The element silicon has been much discussed as a hypothetical alternative to carbon. Silicon is in the same group as carbon on the periodic table and, like carbon, it is tetravalent. Hypothetical alternatives to water include ammonia, which, like water, is a polar molecule, and cosmically abundant; and non-polar hydrocarbon solvents such as methane and ethane, which are known to exist in liquid form on the surface of Titan.

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๐Ÿ”— Free energy principle

๐Ÿ”— Biology ๐Ÿ”— Cognitive science ๐Ÿ”— Neuroscience

The free energy principle tries to explain how (biological) systems maintain their order (non-equilibrium steady-state) by restricting themselves to a limited number of states. It says that biological systems minimise a free energy function of their internal states, which entail beliefs about hidden states in their environment. The implicit minimisation of variational free energy is formally related to variational Bayesian methods and was originally introduced by Karl Friston as an explanation for embodied perception in neuroscience, where it is also known as active inference.

The free energy principle is that systemsโ€”those that are defined by their enclosure in a Markov blanketโ€”try to minimize the difference between their model of the world and their sense and associated perception. This difference can be described as "surprise" and is minimized by continuous correction of the world model of the system. As such, the principle is based on the Bayesian idea of the brain as an โ€œinference engineโ€. Friston added a second route to minimization: action. By actively changing the world into the expected state, systems can also minimize the free energy of the system. Friston assumes this to be the principle of all biological reaction.. Friston also believes his principle applies to mental disorders as well as to artificial intelligence. AI implementations based on the active inference principle have shown advantages over other methods.

The free energy principle has been criticized for being very difficult to understand, even for experts. Discussions of the principle have also been criticized as invoking metaphysical assumptions far removed from a testable scientific prediction, making the principle unfalsifiable. In a 2018 interview, Friston acknowledged that the free energy principle is not properly falsifiable: "the free energy principle is what it is โ€” a principle. Like Hamiltonโ€™s Principle of Stationary Action, it cannot be falsified. It cannot be disproven. In fact, thereโ€™s not much you can do with it, unless you ask whether measurable systems conform to the principle."

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๐Ÿ”— Last universal ancestor

๐Ÿ”— Biology ๐Ÿ”— Genetics ๐Ÿ”— Computational Biology ๐Ÿ”— Evolutionary biology ๐Ÿ”— Human Genetic History

The last universal common ancestor (LUCA), also called the last universal ancestor (LUA),ย or concestor, is the most recent population of organisms from which all organisms now living on Earth have a common descent, the most recent common ancestor of all current life on Earth. (A related concept is that of progenote.) LUCA is not thought to be the first life on Earth but only one of many early organisms, all the others becoming extinct.

While there is no specific fossil evidence of LUCA, it can be studied by comparing the genomes of all modern organisms, its descendants. By this means, a 2016 study identified a set of 355 genes most likely to have been present in LUCA. (However, some of those genes could have developed later, then spread universally by horizontal gene transfer between archaea and bacteria.) The genes describe a complex life form with many co-adapted features, including transcription and translation mechanisms to convert information from DNA to RNA to proteins. The study concluded that the LUCA probably lived in the high-temperature water of deep sea vents near ocean-floor magma flows.

Studies from 2000 to 2018 have suggested an increasingly ancient time for LUCA. In 2000, estimations suggested LUCA existed 3.5 to 3.8 billion years ago in the Paleoarchean era, a few hundred million years after the earliest fossil evidence of life, for which there are several candidates ranging in age from 3.48 to 4.28 billion years ago. A 2018 study from the University of Bristol, applying a molecular clock model, places the LUCA shortly after 4.5 billion years ago, within the Hadean.

Charles Darwin first proposed the theory of universal common descent through an evolutionary process in his book On the Origin of Species in 1859: "Therefore I should infer from analogy that probably all the organic beings which have ever lived on this earth have descended from some one primordial form, into which life was first breathed." Later biologists have separated the problem of the origin of life from that of the LUCA.

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