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🔗 Viruses 🔗 Biology 🔗 Philosophy 🔗 Philosophy/Contemporary philosophy 🔗 History of Science 🔗 Molecular and Cell Biology 🔗 Philosophy/Ethics 🔗 Genetics 🔗 Evolutionary biology 🔗 Science Policy 🔗 Molecular Biology/Molecular and Cell Biology

HeLa (; also Hela or hela) is an immortal cell line used in scientific research. It is the oldest and most commonly used human cell line. The line was derived from cervical cancer cells taken on February 8, 1951 from Henrietta Lacks, a patient who died of cancer on October 4, 1951. The cell line was found to be remarkably durable and prolific, which gives rise to its extensive use in scientific research.

The cells from Lacks's cancerous cervical tumor were taken without her knowledge or consent, which was common practice at the time. Cell biologist George Otto Gey found that they could be kept alive, and developed a cell line. Previously, cells cultured from other human cells would only survive for a few days. Scientists would spend more time trying to keep the cells alive than performing actual research on them. Cells from Lacks' tumor behaved differently. As was custom for Gey's lab assistant, she labeled the culture 'HeLa', the first two letters of the patient's first and last name; this became the name of the cell line.

These were the first human cells grown in a lab that were naturally "immortal", meaning that they do not die after a set number of cell divisions (i.e. cellular senescence). These cells could be used for conducting a multitude of medical experiments—if the cells died, they could simply be discarded and the experiment attempted again on fresh cells from the culture. This represented an enormous boon to medical and biological research, as previously stocks of living cells were limited and took significant effort to culture.

The stable growth of HeLa enabled a researcher at the University of Minnesota hospital to successfully grow polio virus, enabling the development of a vaccine, and by 1952, Jonas Salk developed a vaccine for polio using these cells. To test Salk's new vaccine, the cells were put into mass production in the first-ever cell production factory.

In 1953, HeLa cells were the first human cells successfully cloned and demand for the HeLa cells quickly grew in the nascent biomedical industry. Since the cells' first mass replications, they have been used by scientists in various types of investigations including disease research, gene mapping, effects of toxic substances on organisms, and radiation on humans. Additionally, HeLa cells have been used to test human sensitivity to tape, glue, cosmetics, and many other products.

Scientists have grown an estimated 50 million metric tons of HeLa cells, and there are almost 11,000 patents involving these cells.

The HeLa cell lines are also notorious for invading other cell cultures in laboratory settings. Some have estimated that HeLa cells have contaminated 10–20% of all cell lines currently in use.

🔗 United States 🔗 Biography 🔗 Women scientists 🔗 Biography/science and academia 🔗 Women's History 🔗 History of Science 🔗 Austria 🔗 Jewish Women 🔗 Biography/Actors and Filmmakers

Hedy Lamarr (), born Hedwig Eva Maria Kiesler (November 9, 1914 – January 19, 2000), was an Austrian-born American actress, inventor and film producer. She was part of 30 films in an acting career spanning 28 years, and co-invented an early version of frequency-hopping spread spectrum.

After a brief early film career in Czechoslovakia, including the controversial Ecstasy (1933), she fled from her husband, a wealthy Austrian ammunition manufacturer, and secretly moved to Paris. Traveling to London, she met Louis B. Mayer, head of Metro-Goldwyn-Mayer (MGM) studio, who offered her a movie contract in Hollywood, where he began promoting her as the "world's most beautiful woman".

She became a star with her performance in Algiers (1938), her first film made in the United States. Her MGM films include Lady of the Tropics (1939), Boom Town (1940), H.M. Pulham, Esq. (1941), and White Cargo (1942). Dismayed with her MGM contract, Lamarr co-founded a new production studio and starred in its films including The Strange Woman (1946), and Dishonored Lady (1947). Her greatest success was as Delilah in Cecil B. DeMille's Samson and Delilah (1949). She also acted on television before the release of her final film, The Female Animal (1958). She was honored with a star on the Hollywood Walk of Fame in 1960.

At the beginning of World War II, Lamarr and composer George Antheil developed a radio guidance system for Allied torpedoes, intended to use frequency-hopping spread spectrum technology to defeat the threat of jamming by the Axis powers. She also helped to improve aviation designs for Howard Hughes while they dated during the war. Although the US Navy did not adopt Lamarr and Antheil's invention until 1957, various spread-spectrum techniques are incorporated into Bluetooth technology and are similar to methods used in legacy versions of Wi-Fi. Recognition of the value of their work resulted in the pair being posthumously inducted into the National Inventors Hall of Fame in 2014.

🔗 International relations 🔗 History 🔗 Disaster management 🔗 Medicine 🔗 Viruses 🔗 Lists 🔗 History of Science

This article is a list of deaths caused by an infectious disease. Widespread non-communicable diseases such as cardiovascular disease and cancer are not included.

🔗 Biography 🔗 Religion 🔗 Iran 🔗 Philosophy 🔗 Biography/science and academia 🔗 Astronomy 🔗 History of Science 🔗 Astrology 🔗 Middle Ages 🔗 Islam 🔗 Middle Ages/History 🔗 Central Asia 🔗 Philosophy/Philosophers 🔗 Anthropology 🔗 Watches 🔗 Philosophy/Medieval philosophy 🔗 India

Abu Rayhan al-Biruni (973 – after 1050) was a Persian scholar and polymath. He was from Khwarazm – a region which encompasses modern-day western Uzbekistan, and northern Turkmenistan.

Al-Biruni was well versed in physics, mathematics, astronomy, and natural sciences, and also distinguished himself as a historian, chronologist and linguist. He studied almost all fields of science and was compensated for his research and strenuous work. Royalty and powerful members of society sought out Al-Biruni to conduct research and study to uncover certain findings. He lived during the Islamic Golden Age. In addition to this type of influence, Al-Biruni was also influenced by other nations, such as the Greeks, who he took inspiration from when he turned to studies of philosophy. He was conversant in Khwarezmian, Persian, Arabic, Sanskrit, and also knew Greek, Hebrew and Syriac. He spent much of his life in Ghazni, then capital of the Ghaznavid dynasty, in modern-day central-eastern Afghanistan. In 1017 he travelled to the Indian subcontinent and authored a study of Indian culture Tārīkh al-Hind (History of India) after exploring the Hindu faith practiced in India. He was given the title "founder of Indology". He was an impartial writer on customs and creeds of various nations, and was given the title al-Ustadh ("The Master") for his remarkable description of early 11th-century India.

🔗 History 🔗 Mathematics 🔗 Books 🔗 Greece 🔗 History of Science

The Archimedes Palimpsest is a parchment codex palimpsest, originally a Byzantine Greek copy of a compilation of Archimedes and other authors. It contains two works of Archimedes that were thought to have been lost (the Ostomachion and the Method of Mechanical Theorems) and the only surviving original Greek edition of his work On Floating Bodies. The first version of the compilation is believed to have been produced by Isidorus of Miletus, the architect of the geometrically complex Hagia Sophia cathedral in Constantinople, sometime around AD 530. The copy found in the palimpsest was created from this original, also in Constantinople, during the Macedonian Renaissance (c. AD 950), a time when mathematics in the capital was being revived by the former Greek Orthodox bishop of Thessaloniki Leo the Geometer, a cousin of the Patriarch.

Following the sack of Constantinople by Western crusaders in 1204, the manuscript was taken to an isolated Greek monastery in Palestine, possibly to protect it from occupying crusaders, who often equated Greek script with heresy against their Latin church and either burned or looted many such texts (including at least two other copies of Archimedes). The complex manuscript was not appreciated at this remote monastery and was soon overwritten (1229) with a religious text. In 1899, nine hundred years after it was written, the manuscript was still in the possession of the Greek church, and back in Istanbul, where it was catalogued by the Greek scholar Papadopoulos-Kerameus, attracting the attention of Johan Heiberg. Heiberg visited the church library and was allowed to make detailed photographs in 1906. Most of the original text was still visible, and Heiberg published it in 1915. In 1922 the manuscript went missing in the midst of the evacuation of the Greek Orthodox library in Istanbul, during a tumultuous period following the World War I. Concealed for over 70 years by a Western businessman, forged pictures were painted on top of some text to increase resale value. Unable to sell the book privately, in 1998 the businessman's daughter risked a public auction in New York contested by the Greek church; the U.S. court ruled for the auction, and the manuscript was purchased by an anonymous buyer (rumored to be Jeff Bezos). The texts under the forged pictures, and previously unreadable texts, were revealed by analyzing images produced by ultraviolet, infrared, visible and raking light, and X-ray.

All images and transcriptions are now freely available on the web at the Archimedes Digital Palimpsest under the Creative Commons License CC BY.

🔗 Computing 🔗 Computer science 🔗 Lists 🔗 History of Science 🔗 Bibliographies 🔗 Bibliographies/Science

This is a list of important publications in computer science, organized by field.

Some reasons why a particular publication might be regarded as important:

• Topic creator – A publication that created a new topic
• Breakthrough – A publication that changed scientific knowledge significantly
• Influence – A publication which has significantly influenced the world or has had a massive impact on the teaching of computer science.

🔗 Environment 🔗 London 🔗 History of Science

Fumifugium, or, The inconveniencie of the aer and smoak of London dissipated together with some remedies humbly proposed by J.E. esq. to His Sacred Majestie, and to the Parliament now assembled is a pamphlet published in London, 1661 (see 1661 in literature), by John Evelyn. It is one of the earliest known works on air pollution and is broken down into three parts which explain the problem, a proposed solution, and a way of improvement upon the air in London. The letter was specifically addressed to King Charles II of England and discussed problems with the capital's air pollution dating back to medieval times. Evelyn refers to Greek philosophers, who once believed that air was the principle of the earth and primary substance of the soul up until the time that air pollution began to cause ill health.

Evelyn was appointed to the newly formed Royal Society, and both Society and pamphlet are celebrated in the 1663 "Ballad of Gresham College". Stanza 23 (given here in modern English) describes how Evelyn

[...] shows that 'tis the sea-coal smoke

That always London does environ,
Which does our lungs and spirits choke,
Our hanging spoil, and rust our iron.
Let none at Fumifuge be scoffing

Who heard at Church our Sunday's coughing.

The sea-coal to which Evelyn referred was appropriately named because it came by sea from Newcastle. When burned, it gave off a terrible smell because of high amounts of sulfur in its composition. When burned the sea coal released sulfur dioxide, carbon dioxide, nitric oxide, soot, and particulates of organic matter into the atmosphere. The pamphlet suggests that burning wood, particularly aromatic woods, will be less harmful to the lungs and recommends relocating some of London's more polluting industries outside the capital, in particular lime-burning and brewing.

🔗 United States 🔗 History of Science 🔗 United States/Indiana

The Indiana Pi Bill is the popular name for bill #246 of the 1897 sitting of the Indiana General Assembly, one of the most notorious attempts to establish mathematical truth by legislative fiat. Despite its name, the main result claimed by the bill is a method to square the circle, rather than to establish a certain value for the mathematical constant π, the ratio of the circumference of a circle to its diameter. The bill, written by the crank Edward J. Goodwin, does imply various incorrect values of π, such as 3.2. The bill never became law, due to the intervention of Professor C. A. Waldo of Purdue University, who happened to be present in the legislature on the day it went up for a vote.

The impossibility of squaring the circle using only compass and straightedge constructions, suspected since ancient times, was rigorously proven in 1882 by Ferdinand von Lindemann. Better approximations of π than those implied by the bill have been known since ancient times.

🔗 Lists 🔗 History of Science 🔗 Science

Historians and sociologists have remarked the occurrence, in science, of "multiple independent discovery". Robert K. Merton defined such "multiples" as instances in which similar discoveries are made by scientists working independently of each other. "Sometimes," writes Merton, "the discoveries are simultaneous or almost so; sometimes a scientist will make a new discovery which, unknown to him, somebody else has made years before."

Commonly cited examples of multiple independent discovery are the 17th-century independent formulation of calculus by Isaac Newton, Gottfried Wilhelm Leibniz and others, described by A. Rupert Hall; the 18th-century discovery of oxygen by Carl Wilhelm Scheele, Joseph Priestley, Antoine Lavoisier and others; and the theory of the evolution of species, independently advanced in the 19th century by Charles Darwin and Alfred Russel Wallace.

Multiple independent discovery, however, is not limited to such famous historic instances. Merton believed that it is multiple discoveries, rather than unique ones, that represent the common pattern in science.

Merton contrasted a "multiple" with a "singleton"—a discovery that has been made uniquely by a single scientist or group of scientists working together.

A distinction is drawn between a discovery and an invention, as discussed for example by Bolesław Prus. However, discoveries and inventions are inextricably related, in that discoveries lead to inventions, and inventions facilitate discoveries; and since the same phenomenon of multiplicity occurs in relation to both discoveries and inventions, this article lists both multiple discoveries and multiple inventions.

🔗 History of Science 🔗 Transhumanism

The Drexler–Smalley debate on molecular nanotechnology was a public dispute between K. Eric Drexler, the originator of the conceptual basis of molecular nanotechnology, and Richard Smalley, a recipient of the 1996 Nobel prize in Chemistry for the discovery of the nanomaterial buckminsterfullerene. The dispute was about the feasibility of constructing molecular assemblers, which are molecular machines which could robotically assemble molecular materials and devices by manipulating individual atoms or molecules. The concept of molecular assemblers was central to Drexler's conception of molecular nanotechnology, but Smalley argued that fundamental physical principles would prevent them from ever being possible. The two also traded accusations that the other's conception of nanotechnology was harmful to public perception of the field and threatened continued public support for nanotechnology research.

The debate was carried out from 2001 to 2003 through a series of published articles and open letters. It began with a 2001 article by Smalley in Scientific American, which was followed by a rebuttal published by Drexler and coworkers later that year, and two open letters by Drexler in early 2003. The debate was concluded in late 2003 in a "Point–Counterpoint" feature in Chemical & Engineering News in which both parties participated.

The debate has been often cited in the history of nanotechnology due to the fame of its participants and its commentary on both the technical and social aspects of nanotechnology. It has also been widely criticized for its adversarial tone, with Drexler accusing Smalley of publicly misrepresenting his work, and Smalley accusing Drexler of failing to understand basic science, causing commentators to go so far as to characterize the tone of the debate as similar to "a pissing match" and "reminiscent of [a] Saturday Night Live sketch".