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🔗 Medicine 🔗 Sociology 🔗 Physiology 🔗 Medicine/Cardiology 🔗 Medicine/Society and Medicine

The Roseto effect is the phenomenon by which a close-knit community experiences a reduced rate of heart disease. The effect is named for Roseto, Pennsylvania. The Roseto effect was first noticed in 1961 when the local Roseto doctor encountered Dr. Stewart Wolf, then head of Medicine of the University of Oklahoma, and they discussed, over a couple of beers, the unusually low rate of myocardial infarction in the Italian American community of Roseto compared with other locations. Many studies followed, including a 50-year study comparing Roseto to nearby Bangor. As the original authors had predicted, as the Roseto cohort shed their Italian social structure and became more Americanized in the years following the initial study, heart disease rates increased, becoming similar to those of neighboring towns.

From 1954 to 1961, Roseto had nearly no heart attacks for the otherwise high-risk group of men 55 to 64, and men over 65 had a death rate of 1% while the national average was 2%. Widowers outnumbered widows, as well.

These statistics were at odds with a number of other factors observed in the community. They smoked unfiltered stogies, drank wine "with seeming abandon" in lieu of milk and soft drinks, skipped the Mediterranean diet in favor of meatballs and sausages fried in lard with hard and soft cheeses. The men worked in the slate quarries where they contracted illnesses from gases and dust. Roseto also had no crime, and very few applications for public assistance.

Wolf attributed Rosetans' lower heart disease rate to lower stress. "'The community,' Wolf says, 'was very cohesive. There was no keeping up with the Joneses. Houses were very close together, and everyone lived more or less alike.'" Elders were revered and incorporated into community life. Housewives were respected, and fathers ran the families.

🔗 Biography 🔗 Medicine 🔗 Women's History 🔗 Medicine/Society and Medicine

Henrietta Lacks (born Loretta Pleasant; August 1, 1920 – October 4, 1951) was an African-American woman whose cancer cells are the source of the HeLa cell line, the first immortalized human cell line and one of the most important cell lines in medical research. An immortalized cell line reproduces indefinitely under specific conditions, and the HeLa cell line continues to be a source of invaluable medical data to the present day.

Lacks was the unwitting source of these cells from a tumor biopsied during treatment for cervical cancer at Johns Hopkins Hospital in Baltimore, Maryland, U.S., in 1951. These cells were then cultured by George Otto Gey who created the cell line known as HeLa, which is still used for medical research. As was then the practice, no consent was obtained to culture her cells, nor were she or her family compensated for their extraction or use.

Lacks grew up in rural Virginia. After giving birth to two of their children, she married her cousin David "Day" Lacks. In 1941 the young family moved to Turner Station, near Dundalk, Maryland, in Baltimore County, so Day could work in Bethlehem Steel at Sparrows Point. After Lacks had given birth to their fifth child, Joseph, she was diagnosed with cancer. Tissue samples from her tumors were taken without consent during treatment and these samples were then subsequently cultured into the HeLa cell line.

Even though some information about the origins of HeLa's immortalized cell lines was known to researchers after 1970, the Lacks family was not made aware of the line's existence until 1975. With knowledge of the cell line's genetic provenance becoming public, its use for medical research and for commercial purposes continues to raise concerns about privacy and patients' rights.

🔗 Medicine 🔗 Economics 🔗 Books 🔗 Politics 🔗 Women writers 🔗 Medicine/Psychiatry

The Shock Doctrine: The Rise of Disaster Capitalism is a 2007 book by the Canadian author and social activist Naomi Klein. In the book, Klein argues that neoliberal free market policies (as advocated by the economist Milton Friedman) have risen to prominence in some developed countries because of a deliberate strategy of "shock therapy". This centers on the exploitation of national crises (disasters or upheavals) to establish controversial and questionable policies, while citizens are excessively distracted (emotionally and physically) to engage and develop an adequate response, and resist effectively. The book suggests that some man-made events, such as the Iraq War, were undertaken with the intention of pushing through such unpopular policies in their wake.

Some reviewers criticized the book for making what they viewed as simplifications of political phenomena, while others lauded it as a compelling and important work. The book served as the main source of a 2009 documentary feature film with the same title directed by Michael Winterbottom.

🔗 Medicine 🔗 Health and fitness

The protein leverage hypothesis states that human beings will prioritize the consumption of protein in food over other dietary components, and will eat until protein needs have been met, regardless of energy content, thus leading to over-consumption of foodstuffs when their protein content is low.

This hypothesis has been put forward as a potential explanation of the obesity epidemic. Empirical tests have provided some evidence to confirm the hypothesis with one study suggesting that this could be a link between ultra-processed foods and the prevalence of obesity in the developed world.

In the 1980s, David Raubenheimer and Stephen Simpson, researchers now at the University of Sydney, began to study appetite and food intake in locusts. By studying responses to artificial diets with differing compositions of protein and carbohydrate, they developed the protein leverage hypothesis. Their experiments showed that those who aren't getting enough protein in their diet will continue to be hungry, even when their overall caloric intake is high. "Protein decoys", such as ultraprocessed savory foods that contain little protein (e.g., barbecue chips), are likely to be attractive and to result in overeating. The hormone FGF21, which is released from the liver, can drive savory-seeking behavior under conditions of low protein intake. However, extremely high protein diets can also have drawbacks. In 2020 Simpson and Raubenheimer published the popular science book Eat Like the Animals: What Nature Teaches Us about the Science of Healthy Eating, which details their experiments. For lifelong health they recommend eating a balanced diet with more fiber and fewer fats and carbohydrates rather than an extremely high protein diet.

In 1995, Australian researcher Susanna Holt developed the concept of satiety value, a measure of how much a given food is likely to satisfy the hunger of someone. High protein foods have been found to have high satiety values, though these are outmatched by potatoes and oats (which have a low glycemic index). Fruits rank similarly to high protein foods (likely due to their high level of dietary fibre).

🔗 Medicine

Pyrotherapy (artificial fever) is a method of treatment by raising the body temperature or sustaining an elevated body temperature using a fever. In general, the body temperature was maintained at 41 °C (105 °F). Many diseases were treated by this method in the first half of the 20th century. In general, it was done by exposing the patient to hot baths, warm air, or (electric) blankets. The technique reached its peak of sophistication in the early 20th century with malariotherapy, in which Plasmodium vivax, a causative agent of malaria, was allowed to infect already ill patients in order to produce intense fever for therapeutic ends. The sophistication of this approach lay in using effective anti-malarial drugs to control the P. vivax infection, while maintaining the fever it causes to the detriment of other, ongoing, and then-incurable infections present in the patient, such as late-stage syphilis. This type of pyrotherapy was most famously used by psychiatrist Julius Wagner-Jauregg, who won the Nobel Prize for Medicine in 1927 for his elaboration of the procedure in treating neurosyphilitics.

🔗 Medicine 🔗 Food and drink 🔗 Chemistry 🔗 Medicine/Toxicology

Olestra (also known by its brand name Olean) is a fat substitute that adds no calories to products. It has been used in the preparation of otherwise high-fat foods, thereby lowering or eliminating their fat content. The Food and Drug Administration (FDA) originally approved olestra for use in the US as a replacement for fats and oils in prepackaged ready-to-eat snacks in 1996, concluding that such use "meets the safety standard for food additives, reasonable certainty of no harm".^: 46399 In the late 2000s, olestra lost its popularity due to supposed side effects and has been largely phased out, but products containing the ingredient can still be purchased at grocery stores in some countries. As of 2023, no products are sold in the United States using Olestra.

🔗 Disaster management 🔗 Medicine 🔗 China 🔗 Food and drink 🔗 Medicine/Toxicology 🔗 Taiwan

Gutter oil (Chinese: 地沟油; pinyin: dìgōu yóu, or 餿水油; sōushuǐ yóu) is oil which has been recycled from waste oil collected from sources such as restaurant fryers, grease traps, slaughterhouse waste and fatbergs.

Reprocessing of used cooking oil is often very rudimentary; techniques include filtration, boiling, refining, and the removal of some adulterants. It is then packaged and resold as a cheaper alternative to normal cooking oil. Another version of gutter oil uses discarded animal parts, animal fat and skins, internal organs, and expired or otherwise low-quality meat, which is then cooked in large vats in order to extract the oil. Used kitchen oil can be purchased for between $859 and $937 per ton, while the cleaned and refined product can sell for $1,560 per ton. Thus there is great economic incentive to produce and sell gutter oil.

It was estimated in 2011 that up to one in every ten lower-market restaurant meals consumed in China is prepared with recycled oil. As Feng Ping of the China Meat Research Center has said: "The illegal oil shows no difference in appearance and indicators after refining and purification because the law breakers are skillful at coping with the established standards."

Some street vendors and restaurants in China and Taiwan have illegally used recycled oil unfit for human consumption for the purposes of cooking food, leading to a crackdown against such establishments by the Chinese and Taiwanese governments.

Gutter oil is an acceptable raw ingredient for products that are not for human consumption, such as soap, rubber, bio-fuel, and cosmetics.

🔗 Medicine 🔗 Mexico

The cocoliztli epidemic or the great pestilence is a term given to millions of deaths in the territory of New Spain in present-day Mexico in the 16th century attributed to one or more illnesses collectively called cocoliztli, a mysterious illness characterized by high fevers and bleeding. It ravaged the Mexican highlands in epidemic proportions. The disease became known as Cocoliztli by the native Aztecs, and had devastating effects on the area’s demography, particularly for the indigenous people. Based on the death toll, this outbreak is often referred to as the worst disease epidemic in the history of Mexico. Subsequent outbreaks continued to baffle both Spanish and native doctors, with little consensus among modern researchers on the pathogenesis. However, recent bacterial genomic studies have suggested that Salmonella, specifically a serotype of Salmonella enterica known as Paratyphi C, was at least partially responsible for this initial outbreak. It might have also been an indigenous viral hemorrhagic fever, perhaps exacerbated by the worst droughts to affect that region in 500 years, as well as living conditions for indigenous peoples of Mexico in the wake of the Spanish conquest (c. 1519).

🔗 Medicine 🔗 Viruses

Original antigenic sin, also known as antigenic imprinting or the Hoskins effect, refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to a form of original antigenic sin, termed repertoire freeze.

The phenomenon of original antigenic sin has been described in relation to influenza virus, dengue fever, human immunodeficiency virus (HIV) and to several other viruses.

This phenomenon was first described in 1960 by Thomas Francis Jr. in the article "On the Doctrine of Original Antigenic Sin". It is named by analogy to the theological concept of original sin. According to Francis as cited by Richard Krause:

"The antibody of childhood is largely a response to dominant antigen of the virus causing the first type A influenza infection of the lifetime. [...] The imprint established by the original virus infection governs the antibody response thereafter. This we have called the Doctrine of the Original Antigenic Sin."

🔗 Medicine 🔗 Skepticism 🔗 Alternative medicine

Coley's toxins (also called Coley's toxin, Coley's vaccine, Coley vaccine, Coley's fluid or mixed bacterial vaccine) is a mixture consisting of killed bacteria of species Streptococcus pyogenes and Serratia marcescens, named after William Coley, a surgical oncologist at the Hospital for Special Surgery who developed the mixture in the late 19th century as a treatment for cancer.

There is no evidence that Coley's toxins have any effectiveness in treating cancer, and use of them risks causing serious harm.