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🔗 Medicine 🔗 Food and drink 🔗 Chemistry 🔗 Medicine/Toxicology

Olestra (also known by its brand name Olean) is a fat substitute that adds no calories to products. It has been used in the preparation of otherwise high-fat foods, thereby lowering or eliminating their fat content. The Food and Drug Administration (FDA) originally approved olestra for use in the US as a replacement for fats and oils in prepackaged ready-to-eat snacks in 1996, concluding that such use "meets the safety standard for food additives, reasonable certainty of no harm".^: 46399 In the late 2000s, olestra lost its popularity due to supposed side effects and has been largely phased out, but products containing the ingredient can still be purchased at grocery stores in some countries. As of 2023, no products are sold in the United States using Olestra.

🔗 Disaster management 🔗 Medicine 🔗 China 🔗 Food and drink 🔗 Medicine/Toxicology 🔗 Taiwan

Gutter oil (Chinese: 地沟油; pinyin: dìgōu yóu, or 餿水油; sōushuǐ yóu) is oil which has been recycled from waste oil collected from sources such as restaurant fryers, grease traps, slaughterhouse waste and fatbergs.

Reprocessing of used cooking oil is often very rudimentary; techniques include filtration, boiling, refining, and the removal of some adulterants. It is then packaged and resold as a cheaper alternative to normal cooking oil. Another version of gutter oil uses discarded animal parts, animal fat and skins, internal organs, and expired or otherwise low-quality meat, which is then cooked in large vats in order to extract the oil. Used kitchen oil can be purchased for between $859 and $937 per ton, while the cleaned and refined product can sell for $1,560 per ton. Thus there is great economic incentive to produce and sell gutter oil.

It was estimated in 2011 that up to one in every ten lower-market restaurant meals consumed in China is prepared with recycled oil. As Feng Ping of the China Meat Research Center has said: "The illegal oil shows no difference in appearance and indicators after refining and purification because the law breakers are skillful at coping with the established standards."

Some street vendors and restaurants in China and Taiwan have illegally used recycled oil unfit for human consumption for the purposes of cooking food, leading to a crackdown against such establishments by the Chinese and Taiwanese governments.

Gutter oil is an acceptable raw ingredient for products that are not for human consumption, such as soap, rubber, bio-fuel, and cosmetics.

🔗 Medicine 🔗 Mexico

The cocoliztli epidemic or the great pestilence is a term given to millions of deaths in the territory of New Spain in present-day Mexico in the 16th century attributed to one or more illnesses collectively called cocoliztli, a mysterious illness characterized by high fevers and bleeding. It ravaged the Mexican highlands in epidemic proportions. The disease became known as Cocoliztli by the native Aztecs, and had devastating effects on the area’s demography, particularly for the indigenous people. Based on the death toll, this outbreak is often referred to as the worst disease epidemic in the history of Mexico. Subsequent outbreaks continued to baffle both Spanish and native doctors, with little consensus among modern researchers on the pathogenesis. However, recent bacterial genomic studies have suggested that Salmonella, specifically a serotype of Salmonella enterica known as Paratyphi C, was at least partially responsible for this initial outbreak. It might have also been an indigenous viral hemorrhagic fever, perhaps exacerbated by the worst droughts to affect that region in 500 years, as well as living conditions for indigenous peoples of Mexico in the wake of the Spanish conquest (c. 1519).

🔗 Medicine 🔗 Viruses

Original antigenic sin, also known as antigenic imprinting or the Hoskins effect, refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to a form of original antigenic sin, termed repertoire freeze.

The phenomenon of original antigenic sin has been described in relation to influenza virus, dengue fever, human immunodeficiency virus (HIV) and to several other viruses.

This phenomenon was first described in 1960 by Thomas Francis Jr. in the article "On the Doctrine of Original Antigenic Sin". It is named by analogy to the theological concept of original sin. According to Francis as cited by Richard Krause:

"The antibody of childhood is largely a response to dominant antigen of the virus causing the first type A influenza infection of the lifetime. [...] The imprint established by the original virus infection governs the antibody response thereafter. This we have called the Doctrine of the Original Antigenic Sin."

🔗 Medicine 🔗 Skepticism 🔗 Alternative medicine

Coley's toxins (also called Coley's toxin, Coley's vaccine, Coley vaccine, Coley's fluid or mixed bacterial vaccine) is a mixture consisting of killed bacteria of species Streptococcus pyogenes and Serratia marcescens, named after William Coley, a surgical oncologist at the Hospital for Special Surgery who developed the mixture in the late 19th century as a treatment for cancer.

There is no evidence that Coley's toxins have any effectiveness in treating cancer, and use of them risks causing serious harm.

🔗 Biography 🔗 California 🔗 California/San Francisco Bay Area 🔗 Medicine 🔗 Physics 🔗 Women scientists 🔗 Biography/science and academia 🔗 Women's History 🔗 Physics/Biographies 🔗 Medicine/Radiology

Elizabeth Fleischman-Aschheim (née Fleischman 5 March 1867 – 3 August 1905) was an American radiographer who is considered an X-ray pioneer. Fleischman was the first woman to die as a result of X-ray radiation exposure.

🔗 Military history 🔗 Military history/Military science, technology, and theory 🔗 Military history/Weaponry 🔗 Medicine 🔗 Chemicals 🔗 Occupational Safety and Health 🔗 Military history/World War I 🔗 Medicine/Toxicology

Chloropicrin, also known as PS and nitrochloroform, is a chemical compound currently used as a broad-spectrum antimicrobial, fungicide, herbicide, insecticide, and nematicide. It was used as a poison gas in World War I. Its chemical structural formula is Cl₃CNO₂.

🔗 Medicine

A vaccine-preventable disease is an infectious disease for which an effective preventive vaccine exists. If a person acquires a vaccine-preventable disease and dies from it, the death is considered a vaccine-preventable death.

The most common and serious vaccine-preventable diseases tracked by the World Health Organization (WHO) are: diphtheria, Haemophilus influenzae serotype b infection, hepatitis B, measles, meningitis, mumps, pertussis, poliomyelitis, rubella, tetanus, tuberculosis, and yellow fever. The WHO reports licensed vaccines being available to prevent, or contribute to the prevention and control of, 27 vaccine-preventable infections.

🔗 Medicine

In medicine, the hygiene hypothesis states that early childhood exposure to particular microorganisms (such as the gut flora and helminth parasites) protects against allergies by properly tuning the immune system. In particular, a lack of such exposure is thought to lead to poor immune tolerance. The time period for exposure begins before birth and ends at school age.

While early versions of the hypothesis referred to microorganism exposure in general, later versions apply to a specific set of microbes that have co-evolved with humans. The updates have been given various names, including the microbiome depletion hypothesis, the microflora hypothesis, and the "old friends" hypothesis. There is a significant amount of evidence supporting the idea that lack of exposure to these microbes is linked to allergies or other conditions, although it is still rejected by many scientists.

The term "hygiene hypothesis" has been described as a misnomer because people incorrectly interpret it as referring to their own cleanliness. Having worse personal hygiene, such as not washing hands before eating, only increases the risk of infection without affecting the risk of allergies or immune disorders. Hygiene is essential for protecting vulnerable populations such as the elderly from infections, preventing the spread of antibiotic resistance, and combating emerging infectious diseases such as Ebola. The hygiene hypothesis does not suggest that having more infections during childhood would be an overall benefit.

🔗 Medicine 🔗 Skepticism 🔗 Anthropology 🔗 Medicine/Psychiatry

In medicine and medical anthropology, a culture-bound syndrome, culture-specific syndrome, or folk illness is a combination of psychiatric and somatic symptoms that are considered to be a recognizable disease only within a specific society or culture. There are no objective biochemical or structural alterations of body organs or functions, and the disease is not recognized in other cultures. The term culture-bound syndrome was included in the fourth version of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 1994) which also includes a list of the most common culture-bound conditions (DSM-IV: Appendix I). Counterpart within the framework of ICD-10 (Chapter V) are the culture-specific disorders defined in Annex 2 of the Diagnostic criteria for research.

More broadly, an endemic that can be attributed to certain behavior patterns within a specific culture by suggestion may be referred to as a potential behavioral epidemic. As in the cases of drug use, or alcohol and smoking abuses, transmission can be determined by communal reinforcement and person-to-person interactions. On etiological grounds, it can be difficult to distinguish the causal contribution of culture upon disease from other environmental factors such as toxicity.