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🔗 Medicine 🔗 Pharmacology

Sofosbuvir, sold under the brand name Sovaldi among others, is a medication used to treat hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir, daclatasvir, or velpatasvir. Cure rates are 30 to 97% depending on the type of hepatitis C virus involved. Safety during pregnancy is unclear; some of the medications used in combination may result in harm to the baby. It is taken by mouth.

Common side effects include feeling tired, headache, nausea, and trouble sleeping. Side effects are generally more common in interferon-containing regimens. Sofosbuvir may reactivate hepatitis B in those who have been previously infected. In combination with ledipasvir, daclatasvir or simeprevir it is not recommended with amiodarone due to the risk of an abnormally slow heartbeat. Sofosbuvir is in the nucleotide analog family of medication and works by blocking the hepatitis C NS5B protein.

Sofosbuvir was discovered in 2007, and approved for medical use in the United States in 2013. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. As of 2016, a 12-week course of treatment costs about US$84,000 in the United States, US$53,000 in the United Kingdom, US$45,000 in Canada, and about US$500 in India. Over 60,000 people were treated with sofosbuvir in its first 30 weeks being sold in the United States.

🔗 Medicine 🔗 China 🔗 Plants 🔗 Pharmacology 🔗 Psychoactive and Recreational Drugs

For over two millennia, texts in Chinese herbology and traditional Chinese medicine have recorded medicinal plants that are also hallucinogens and psychedelics. Some are familiar psychoactive plants in Western herbal medicine (e.g., Chinese: 莨菪; pinyin: làngdàng, i.e. Hyoscyamus niger), but several Chinese plants have not been noted as hallucinogens in modern works (e.g.,Chinese: 雲實; pinyin: yúnshí; lit. 'cloud seed', i.e. Caesalpinia decapetala). Chinese herbals are an important resource for the history of botany, for instance, Zhang Hua's c. 290 Bowuzhi is the earliest record of the psilocybin mushroom xiàojùn 笑菌 (lit. "laughing mushroom", i.e. Gymnopilus junonius).

🔗 Medicine

The choking game (also known as the fainting game and a wide variety of slang terms) refers to intentionally cutting off oxygen to the brain with the goal of inducing temporary loss of consciousness and euphoria.

🔗 Medicine 🔗 Medicine/Neurology 🔗 Epilepsy

Musicogenic seizure, also known as music-induced seizure, is a rare type of seizure, with an estimated prevalence of 1 in 10,000,000 individuals, that arises from disorganized or abnormal brain electrical activity when a person hears or is exposed to a specific type of sound or musical stimuli. There are challenges when diagnosing a music-induced seizure due to the broad scope of triggers, and time delay between a stimulus and seizure. In addition, the causes of musicogenic seizures are not well-established as solely limited cases and research have been discovered and conducted respectively. Nevertheless, the current understanding of the mechanism behind musicogenic seizure is that music triggers the part of the brain that is responsible for evoking an emotion associated with that music. Dysfunction in this system leads to an abnormal release of dopamine, eventually inducing seizure.

Currently, there are diverse intervention strategies that patients can choose from depending on their situations. They can have surgery to remove the region of the brain that generates a seizure. Behavioral therapy is also available; patients are trained to gain emotional control to reduce the frequency of seizure. Medications like carbamazepine and phenytoin (medication for general seizure) also suggest effectiveness to mitigate music-induced seizures.

🔗 Medicine 🔗 Viruses 🔗 Dogs 🔗 Cats 🔗 Neuroscience 🔗 Microbiology 🔗 Medicine/Neurology 🔗 Rodents 🔗 Medicine/Translation 🔗 Veterinary medicine 🔗 Medicine/Dermatology

Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: violent movements, uncontrolled excitement, fear of water, an inability to move parts of the body, confusion, and loss of consciousness. Once symptoms appear, the result is nearly always death. The time period between contracting the disease and the start of symptoms is usually one to three months, but can vary from less than one week to more than one year. The time depends on the distance the virus must travel along peripheral nerves to reach the central nervous system.

Rabies is caused by lyssaviruses, including the rabies virus and Australian bat lyssavirus. It is spread when an infected animal bites or scratches a human or other animal. Saliva from an infected animal can also transmit rabies if the saliva comes into contact with the eyes, mouth, or nose. Globally, dogs are the most common animal involved. In countries where dogs commonly have the disease, more than 99% of rabies cases are the direct result of dog bites. In the Americas, bat bites are the most common source of rabies infections in humans, and less than 5% of cases are from dogs. Rodents are very rarely infected with rabies. The disease can be diagnosed only after the start of symptoms.

Animal control and vaccination programs have decreased the risk of rabies from dogs in a number of regions of the world. Immunizing people before they are exposed is recommended for those at high risk, including those who work with bats or who spend prolonged periods in areas of the world where rabies is common. In people who have been exposed to rabies, the rabies vaccine and sometimes rabies immunoglobulin are effective in preventing the disease if the person receives the treatment before the start of rabies symptoms. Washing bites and scratches for 15 minutes with soap and water, povidone-iodine, or detergent may reduce the number of viral particles and may be somewhat effective at preventing transmission. As of 2016, only fourteen people had survived a rabies infection after showing symptoms.

Rabies caused about 17,400 human deaths worldwide in 2015. More than 95% of human deaths from rabies occur in Africa and Asia. About 40% of deaths occur in children under the age of 15. Rabies is present in more than 150 countries and on all continents but Antarctica. More than 3 billion people live in regions of the world where rabies occurs. A number of countries, including Australia and Japan, as well as much of Western Europe, do not have rabies among dogs. Many Pacific islands do not have rabies at all. It is classified as a neglected tropical disease.

🔗 Medicine 🔗 Ancient Egypt

The Ebers Papyrus, also known as Papyrus Ebers, is an Egyptian medical papyrus of herbal knowledge dating to circa 1550 BC. Among the oldest and most important medical papyri of ancient Egypt, it was purchased at Luxor in the winter of 1873–74 by Georg Ebers. It is currently kept at the library of the University of Leipzig, in Germany.

🔗 Medicine 🔗 Medicine/Pulmonology 🔗 Plants 🔗 Horticulture and Gardening 🔗 Medicine/Society and Medicine

Botanical sexism is a term coined by horticulturist Tom Ogren to describe the planting of male plants instead of female plants of certain dioecious species including: willows, poplars, aspens, ashes, silver maples, pistache, mulberry, pepper tree and other woody plants such as junipers, yew pines, fern pines, wax myrtles, alpine currants, plum yews, and yews According to Ogren, pollen allergies have been amplified due to the planting in urban areas of male clones which increases the amount of pollen in the air. Male plants are commonly used in urban areas because plants with female flowers produce fruits and flowers that litter the landscape. The planting of more female plants would decrease the overall amount of pollen since they do not produce pollen and remove pollen from the air for pollination. The theory has existed since at least the 2000s. Biological sexism is used in the Ogren Plant Allergy Scale (OPALS), which has been adopted by the United States Department of Agriculture. Botanical sexism has found some scientific acceptance as a reason for increased allergies and asthma; however, other scientists have also been critical of it, stating that it only applies to certain trees and is not as widespread as Ogren alleges.

🔗 Medicine 🔗 Lists 🔗 Countries

This is a list of countries by hospital beds per 1000 or 100,000 people, as published by the local governments, international organisation (OECD, E.U.), academic sources or others. The number of beds per people is an important indicator of the health care system of a country. The basic measure focus on all hospital beds, which are variously split and occupied. The classic hospital beds are also called curative beds. For severe patients with risk of organ(s) failure, patients are provided intensive care unit beds (aka ICU bed) or critical care beds (CCB).

Among OECD countries, curative beds' occupancy rate average was 75%, from 94.9% (Ireland) to 61.6% (Greece), with half of the OECD's nation between 70% and 80%.

In 2009, European nations, most of them also part of OECD, had an aggregated total of 2,070,000 acute beds and 73,585 (2.8%) critical care beds (CCB) or 11.5CCB/100,000 inhabitants. Germany had 29.2, Portugal 4.2.Aging population leads to increased demand for CCB and difficulties to satisfy it, while both quantity of CCB and availability are poorly documented.

🔗 Medicine 🔗 Psychoactive and Recreational Drugs

A form constant is one of several geometric patterns which are recurringly observed during hypnagogia, hallucinations and altered states of consciousness.

🔗 Medicine 🔗 Psychology

Posttraumatic Embitterment Disorder (PTED) is defined as a pathological reaction to a negative life event, which those affected experienced as a grave insult, humiliation, betrayal, or injustice. Prevalent emotions of PTED are embitterment, anger, fury, and hatred, especially against the triggering stressor, often accompanied by fantasies of revenge. The disorder commences immediately and without time delay at the moment of the triggering event. If left untreated, the prognosis of PTED presents as rather unfavorable, since patients find themselves trapped in a vicious circle of strong negative emotions constantly intensifying one another and eventually leading into a self-destructive downward spiral. People affected by PTED are more likely to put fantasies of revenge into action, making them a serious threat to the stressor.

The concept of PTED as a distinct clinical disorder has been first described by the German psychiatrist and psychologist Michael Linden in 2003, who remains its most involved researcher. Even though it has been backed up by empirical research in the past years, it remains disputed as to whether embitterment should be included among psychological disorders. Therefore, PTED currently does not hold its own category in the ICD-10 but is categorized under F43.8 “Other reactions to severe stress”. It cannot be categorized as an adjustment disorder under F43.2, since “ordinary” adjustment disorders normally subside within six months, while PTED is much more likely to become chronical and last for much longer. A condition similar to PTED has already been described by Emil Kraepelin as early as 1915 by the name querulous paranoia as a form of traumatic neuroses, explicitly demarcating it from personality disorders.