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🔗 Technology 🔗 Computing 🔗 Medicine 🔗 Molecular and Cell Biology 🔗 Medicine/Medical genetics

DNA digital data storage is the process of encoding and decoding binary data to and from synthesized strands of DNA.

While DNA as a storage medium has enormous potential because of its high storage density, its practical use is currently severely limited because of its high cost and very slow read and write times.

In June 2019, scientists reported that all 16 GB of text from Wikipedia's English-language version have been encoded into synthetic DNA.

🔗 Medicine 🔗 Transhumanism 🔗 Neuroscience 🔗 Pharmacology 🔗 Psychoactive and Recreational Drugs

Modafinil, sold under the brand name Provigil among others, is a medication to treat sleepiness due to narcolepsy, shift work sleep disorder, or obstructive sleep apnea. While it has seen off-label use as a purported cognitive enhancer, the research on its effectiveness for this use is not conclusive. It is taken by mouth.

Common side effects include headache, anxiety, trouble sleeping, and nausea. Serious side effects may include allergic reactions such as anaphylaxis, Stevens–Johnson syndrome, misuse, and hallucinations. It is unclear if use during pregnancy is safe. The amount of medication used may need to be adjusted in those with kidney or liver problems. It is not recommended in those with an arrhythmia, significant hypertension, or left ventricular hypertrophy. How it works is not entirely clear. One possibility is that it may affect the areas of the brain involved with the sleep cycle.

Modafinil was approved for medical use in the United States in 1998. In the United States it is classified as a schedule IV controlled substance. In the United Kingdom it is a prescription only medication. It is available as a generic medication. In the United Kingdom it costs the NHS about £105.21 a month as of 2018. In the United States the wholesale cost per month is about US$34.20 as of 2018. In 2016, it was the 284th most prescribed medication in the United States, with more than a million prescriptions.

🔗 Medicine 🔗 Death 🔗 Health and fitness 🔗 Japan 🔗 Medicine/Society and Medicine 🔗 Japan/Culture 🔗 Japan/Science and technology

Karoshi (過労死, Karōshi), which can be translated literally as "overwork death" in Japanese, is occupational sudden mortality. The major medical causes of karoshi deaths are heart attack and stroke due to stress and a starvation diet. This phenomenon is also widespread in other parts of Asia.

🔗 Medicine 🔗 Conservatism

Ronald Reagan Speaks Out Against Socialized Medicine is a 1961 LP featuring the actor Ronald Reagan. In this more than ten-minute recording, Reagan "criticized Social Security for supplanting private savings and warned that subsidized medicine would curtail Americans' freedom" and that "pretty soon your son won't decide when he's in school, where he will go or what he will do for a living. He will wait for the government to tell him." Roger Lowenstein called the LP part of a "stealth program" conducted by the American Medical Association (see Operation Coffee Cup).

🔗 History 🔗 Disaster management 🔗 Medicine 🔗 Viruses 🔗 Death 🔗 Globalization

The Spanish flu (also known as the 1918 flu pandemic) was an unusually deadly influenza pandemic. Lasting from January 1918 to December 1920, it infected 500 million people—about a quarter of the world's population at the time. The death toll is estimated to have been anywhere from 17 million to 50 million, and possibly as high as 100 million, making it one of the deadliest pandemics in human history.

To maintain morale, World War I censors minimized early reports of illness and mortality in Germany, the United Kingdom, France, and the United States. Papers were free to report the epidemic's effects in neutral Spain, such as the grave illness of King Alfonso XIII, and these stories created a false impression of Spain as especially hard hit. This gave rise to the pandemic's nickname, "Spanish flu". Historical and epidemiological data are inadequate to identify with certainty the pandemic's geographic origin, with varying views as to the origin.

Most influenza outbreaks disproportionately kill the very young and the very old, with a higher survival rate for those in between, but the Spanish flu pandemic resulted in a higher than expected mortality rate for young adults. Scientists offer several possible explanations for the high mortality rate of the 1918 influenza pandemic. Some analyses have shown the virus to be particularly deadly because it triggers a cytokine storm, which ravages the stronger immune system of young adults. In contrast, a 2007 analysis of medical journals from the period of the pandemic found that the viral infection was no more aggressive than previous influenza strains. Instead, malnourishment, overcrowded medical camps and hospitals, and poor hygiene promoted bacterial superinfection. This superinfection killed most of the victims, typically after a somewhat prolonged death bed.

The Spanish flu was the first of two pandemics caused by the H1N1 influenza virus; the second was the swine flu in 2009.

🔗 Medicine 🔗 Ageing and culture

Old person smell is the characteristic odor of elderly humans. Much like many animal species, human odor undergoes distinct stages based on chemical changes initiated through the aging process. Research suggests that this enables humans to determine the suitability of potential partners based on age, in addition to other factors.

One study suggested that old person smell may be the result of 2-nonenal, an unsaturated aldehyde which is associated with human body odor alterations during aging; however, there are other hypotheses. Another study failed to detect 2-nonenal at all, but found significantly increased concentrations of benzothiazole, dimethylsulphone, and nonanal on older subjects.

In 2012 the Monell Chemical Senses Center published a press release claiming that the human ability to identify information such as age, illness, and genetic suitability from odor is responsible for the distinctive "old man smell". Sensory neuroscientist Johan Lundström stated, "Elderly people have a discernible underarm odor that younger people consider to be fairly neutral and not very unpleasant."

Old person smell is known as kareishū (加齢臭) in Japan, where much social value is placed on personal grooming, and specific upmarket odor-eliminating soaps are targeted at more elderly consumers.

🔗 Medicine 🔗 Psychology 🔗 Sociology 🔗 Science 🔗 Academic Journals

The replication crisis (or replicability crisis or reproducibility crisis) is, as of 2020, an ongoing methodological crisis in which it has been found that many scientific studies are difficult or impossible to replicate or reproduce. The replication crisis affects the social sciences and medicine most severely. The crisis has long-standing roots; the phrase was coined in the early 2010s as part of a growing awareness of the problem. The replication crisis represents an important body of research in the field of metascience.

Because the reproducibility of experimental results is an essential part of the scientific method, the inability to replicate the studies of others has potentially grave consequences for many fields of science in which significant theories are grounded on unreproducible experimental work. The replication crisis has been particularly widely discussed in the field of psychology and in medicine, where a number of efforts have been made to re-investigate classic results, to determine both the reliability of the results, and, if found to be unreliable, the reasons for the failure of replication.

🔗 Internet culture 🔗 Medicine 🔗 Psychology 🔗 Electronic music 🔗 Neuroscience 🔗 Medicine/Neurology 🔗 Medicine/Society and Medicine 🔗 Albums

Everywhere at the End of Time is the eleventh recording by the Caretaker, an alias of English electronic musician Leyland Kirby. Released between 2016 and 2019, its six studio albums use degrading loops of sampled ballroom music to portray the progression of Alzheimer's disease. Inspired by the success of An Empty Bliss Beyond This World (2011), Kirby produced Everywhere as his final major work under the alias. The albums were produced in Krakow and released over six-month periods to "give a sense of time passing". The album covers are abstract paintings by his friend Ivan Seal. The series drew comparisons to the works of composer William Basinski and electronic musician Burial; later stages were influenced by avant-gardist composer John Cage.

The series comprises six hours of music, portraying a range of emotions and characterised by noise throughout. Although the first three stages are similar to An Empty Bliss, the last three stages depart from Kirby's earlier ambient works. The albums reflect the patient's disorder and death, their feelings, and the phenomenon of terminal lucidity. To promote the series, Kirby partnered with anonymous visual artist Weirdcore to make music videos. At first, concerned about whether the series would seem pretentious, Kirby thought of not creating Everywhere at all; he spent more time producing it than any of his other releases. The album covers received attention from a French art exhibition named after the Caretaker's Everywhere, an Empty Bliss (2019), a compilation of archived songs.

As each stage was released, the series received increasingly positive reviews from critics; its length and dementia-driven concept led many reviewers to feel emotional about the complete edition. Considered to be Kirby's magnum opus, Everywhere was one of the most praised music releases of the 2010s. Caregivers of people with dementia also praised the albums for increasing empathy for patients among younger listeners, although some medics felt the series was too linear. It became an Internet phenomenon in the early 2020s, emerging in TikTok videos as a listening challenge, being transformed into a mod for the video game Friday Night Funkin' (2020), and appearing in internet memes.

🔗 Human rights 🔗 Medicine 🔗 History of Science 🔗 Alabama 🔗 Science Policy 🔗 Nursing

The Tuskegee Study of Untreated Syphilis in the Negro Male (informally referred to as the Tuskegee Experiment or Tuskegee Syphilis Study) was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Centers for Disease Control and Prevention (CDC) on a group of nearly 400 African American men with syphilis. The purpose of the study was to observe the effects of the disease when untreated, though by the end of the study medical advancements meant it was entirely treatable. The men were not informed of the nature of the experiment, and more than 100 died as a result.

The Public Health Service started the study in 1932 in collaboration with Tuskegee University (then the Tuskegee Institute), a historically Black college in Alabama. In the study, investigators enrolled a total of 600 impoverished African-American sharecroppers from Macon County, Alabama. Of these men, 399 had latent syphilis, with a control group of 201 men who were not infected. As an incentive for participation in the study, the men were promised free medical care. While the men were provided with both medical and mental care that they otherwise would not have received, they were deceived by the PHS, who never informed them of their syphilis diagnosis and provided disguised placebos, ineffective methods, and diagnostic procedures as treatment for "bad blood".

The men were initially told that the experiment was only going to last six months, but it was extended to 40 years. After funding for treatment was lost, the study was continued without informing the men that they would never be treated. None of the infected men were treated with penicillin despite the fact that, by 1947, the antibiotic was widely available and had become the standard treatment for syphilis.

The study continued, under numerous Public Health Service supervisors, until 1972, when a leak to the press resulted in its termination on November 16 of that year. By then, 28 patients had died directly from syphilis, 100 died from complications related to syphilis, 40 of the patients' wives were infected with syphilis, and 19 children were born with congenital syphilis.

The 40-year Tuskegee Study was a major violation of ethical standards and has been cited as "arguably the most infamous biomedical research study in U.S. history." Its revelation led to the 1979 Belmont Report and to the establishment of the Office for Human Research Protections (OHRP) and federal laws and regulations requiring institutional review boards for the protection of human subjects in studies. The OHRP manages this responsibility within the United States Department of Health and Human Services (HHS). Its revelation has also been an important cause of distrust in medical science and the US government amongst African Americans.

On May 16, 1997, President Bill Clinton formally apologized on behalf of the United States to victims of the study, calling it shameful and racist. "What was done cannot be undone, but we can end the silence," he said. "We can stop turning our heads away. We can look at you in the eye, and finally say, on behalf of the American people, what the United States government did was shameful and I am sorry."

🔗 Medicine 🔗 Science

The aesthetic–usability effect describes a paradox that people perceive more aesthetic designs as much more intuitive than those considered to be less aesthetically pleasing. The effect has been observed in several experiments and has significant implications regarding the acceptance, use, and performance of a design. Usability and aesthetics are the two most important factors in assessing the overall user experience for an application. Usability and aesthetics are judged by a user's reuse expectations, and then their post-use, or experienced, final judgement. A user's cognitive style can influence how they interact with and perceive an application, which in turn can influence their judgement of the application.