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🔗 Medicine 🔗 Psychology 🔗 Sociology 🔗 Science 🔗 Academic Journals

The replication crisis (or replicability crisis or reproducibility crisis) is, as of 2020, an ongoing methodological crisis in which it has been found that many scientific studies are difficult or impossible to replicate or reproduce. The replication crisis affects the social sciences and medicine most severely. The crisis has long-standing roots; the phrase was coined in the early 2010s as part of a growing awareness of the problem. The replication crisis represents an important body of research in the field of metascience.

Because the reproducibility of experimental results is an essential part of the scientific method, the inability to replicate the studies of others has potentially grave consequences for many fields of science in which significant theories are grounded on unreproducible experimental work. The replication crisis has been particularly widely discussed in the field of psychology and in medicine, where a number of efforts have been made to re-investigate classic results, to determine both the reliability of the results, and, if found to be unreliable, the reasons for the failure of replication.

🔗 Internet culture 🔗 Medicine 🔗 Psychology 🔗 Electronic music 🔗 Neuroscience 🔗 Medicine/Neurology 🔗 Medicine/Society and Medicine 🔗 Albums

Everywhere at the End of Time is the eleventh recording by the Caretaker, an alias of English electronic musician Leyland Kirby. Released between 2016 and 2019, its six studio albums use degrading loops of sampled ballroom music to portray the progression of Alzheimer's disease. Inspired by the success of An Empty Bliss Beyond This World (2011), Kirby produced Everywhere as his final major work under the alias. The albums were produced in Krakow and released over six-month periods to "give a sense of time passing". The album covers are abstract paintings by his friend Ivan Seal. The series drew comparisons to the works of composer William Basinski and electronic musician Burial; later stages were influenced by avant-gardist composer John Cage.

The series comprises six hours of music, portraying a range of emotions and characterised by noise throughout. Although the first three stages are similar to An Empty Bliss, the last three stages depart from Kirby's earlier ambient works. The albums reflect the patient's disorder and death, their feelings, and the phenomenon of terminal lucidity. To promote the series, Kirby partnered with anonymous visual artist Weirdcore to make music videos. At first, concerned about whether the series would seem pretentious, Kirby thought of not creating Everywhere at all; he spent more time producing it than any of his other releases. The album covers received attention from a French art exhibition named after the Caretaker's Everywhere, an Empty Bliss (2019), a compilation of archived songs.

As each stage was released, the series received increasingly positive reviews from critics; its length and dementia-driven concept led many reviewers to feel emotional about the complete edition. Considered to be Kirby's magnum opus, Everywhere was one of the most praised music releases of the 2010s. Caregivers of people with dementia also praised the albums for increasing empathy for patients among younger listeners, although some medics felt the series was too linear. It became an Internet phenomenon in the early 2020s, emerging in TikTok videos as a listening challenge, being transformed into a mod for the video game Friday Night Funkin' (2020), and appearing in internet memes.

🔗 Medicine 🔗 Medicine/Neurology

Gourmand syndrome is a very rare and benign eating disorder that usually occurs six to twelve months after an injury to the frontal lobe. Those with the disorder usually have a right hemisphere frontal or temporal brain lesion typically affecting the cortical areas, basal ganglia or limbic structures. These people develop a new, post-injury passion for gourmet food.

There are two main aspects of gourmand syndrome: first, the fine dining habits and changes to taste, and second, an obsessive component which may result in craving and preservation. Gourmand syndrome can be related to, and shares biological features with, addictive and obsessive disorders. The syndrome was first characterized in 1997.

🔗 Human rights 🔗 Medicine 🔗 History of Science 🔗 Alabama 🔗 Science Policy 🔗 Nursing

The Tuskegee Study of Untreated Syphilis in the Negro Male (informally referred to as the Tuskegee Experiment or Tuskegee Syphilis Study) was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Centers for Disease Control and Prevention (CDC) on a group of nearly 400 African American men with syphilis. The purpose of the study was to observe the effects of the disease when untreated, though by the end of the study medical advancements meant it was entirely treatable. The men were not informed of the nature of the experiment, and more than 100 died as a result.

The Public Health Service started the study in 1932 in collaboration with Tuskegee University (then the Tuskegee Institute), a historically Black college in Alabama. In the study, investigators enrolled a total of 600 impoverished African-American sharecroppers from Macon County, Alabama. Of these men, 399 had latent syphilis, with a control group of 201 men who were not infected. As an incentive for participation in the study, the men were promised free medical care. While the men were provided with both medical and mental care that they otherwise would not have received, they were deceived by the PHS, who never informed them of their syphilis diagnosis and provided disguised placebos, ineffective methods, and diagnostic procedures as treatment for "bad blood".

The men were initially told that the experiment was only going to last six months, but it was extended to 40 years. After funding for treatment was lost, the study was continued without informing the men that they would never be treated. None of the infected men were treated with penicillin despite the fact that, by 1947, the antibiotic was widely available and had become the standard treatment for syphilis.

The study continued, under numerous Public Health Service supervisors, until 1972, when a leak to the press resulted in its termination on November 16 of that year. By then, 28 patients had died directly from syphilis, 100 died from complications related to syphilis, 40 of the patients' wives were infected with syphilis, and 19 children were born with congenital syphilis.

The 40-year Tuskegee Study was a major violation of ethical standards and has been cited as "arguably the most infamous biomedical research study in U.S. history." Its revelation led to the 1979 Belmont Report and to the establishment of the Office for Human Research Protections (OHRP) and federal laws and regulations requiring institutional review boards for the protection of human subjects in studies. The OHRP manages this responsibility within the United States Department of Health and Human Services (HHS). Its revelation has also been an important cause of distrust in medical science and the US government amongst African Americans.

On May 16, 1997, President Bill Clinton formally apologized on behalf of the United States to victims of the study, calling it shameful and racist. "What was done cannot be undone, but we can end the silence," he said. "We can stop turning our heads away. We can look at you in the eye, and finally say, on behalf of the American people, what the United States government did was shameful and I am sorry."

🔗 Medicine 🔗 Science

The aesthetic–usability effect describes a paradox that people perceive more aesthetic designs as much more intuitive than those considered to be less aesthetically pleasing. The effect has been observed in several experiments and has significant implications regarding the acceptance, use, and performance of a design. Usability and aesthetics are the two most important factors in assessing the overall user experience for an application. Usability and aesthetics are judged by a user's reuse expectations, and then their post-use, or experienced, final judgement. A user's cognitive style can influence how they interact with and perceive an application, which in turn can influence their judgement of the application.

🔗 Medicine 🔗 Biology 🔗 Skepticism 🔗 Transhumanism 🔗 Alternative Views 🔗 Guild of Copy Editors 🔗 Alternative medicine 🔗 Longevity

Life extension is the idea of extending the human lifespan, either modestly – through improvements in medicine – or dramatically by increasing the maximum lifespan beyond its generally settled limit of 125 years. The ability to achieve such dramatic changes, however, does not currently exist.

Some researchers in this area, and "life extensionists", "immortalists" or "longevists" (those who wish to achieve longer lives themselves), believe that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition. The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists.

The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that promotes the use of hormones as a treatment for consumers to slow or reverse the aging process in the US market generated about $50 billion of revenue a year in 2009. The use of such products has not been proven to be effective or safe.

🔗 Medicine

This list of laboratory biosecurity incidents includes accidental laboratory-acquired infections and laboratory releases of lethal pathogens, containment failures in or during transport of lethal pathogens, and incidents of exposure of lethal pathogens to laboratory personnel, improper disposal of contaminated waste, and/or the escape of laboratory animals. The list is grouped by the year in which the accident or incident occurred and does not include every reported laboratory-acquired infection.

🔗 Medicine 🔗 Psychology

Type A and Type B personality hypothesis describes two contrasting personality types. In this hypothesis, personalities that are more competitive, highly organized, ambitious, impatient, highly aware of time management and/or aggressive are labeled Type A, while more relaxed, less 'neurotic', 'frantic', 'explainable', personalities are labeled Type B.

The two cardiologists who developed this theory came to believe that Type A personalities had a greater chance of developing coronary heart disease. Following the results of further studies and considerable controversy about the role of the tobacco industry funding of early research in this area, some reject, either partially or completely, the link between Type A personality and coronary disease. Nevertheless, this research had a significant effect on the development of the health psychology field, in which psychologists look at how an individual's mental state affects physical health.

🔗 Medicine 🔗 History of Science

Mummia, mumia, or originally mummy referred to several different preparations in the history of medicine, from "mineral pitch" to "powdered human mummies". It originated from Arabic mūmiyā "a type of resinous bitumen found in Western Asia and used curatively" in traditional Islamic medicine, which was translated as pissasphaltus (from "pitch" and "asphalt") in ancient Greek medicine. In medieval European medicine, mūmiyā "bitumen" was transliterated into Latin as mumia meaning both "a bituminous medicine from Persia" and "mummy". Merchants in apothecaries dispensed expensive mummia bitumen, which was thought to be an effective cure-all for many ailments. It was also used as an aphrodisiac. Beginning around the 12th century when supplies of imported natural bitumen ran short, mummia was misinterpreted as "mummy", and the word's meaning expanded to "a black resinous exudate scraped out from embalmed Egyptian mummies". This began a period of lucrative trade between Egypt and Europe, and suppliers substituted rare mummia exudate with entire mummies, either embalmed or desiccated. After Egypt banned the shipment of mummia in the 16th century, unscrupulous European apothecaries began to sell fraudulent mummia prepared by embalming and desiccating fresh corpses. During the Renaissance, scholars proved that translating bituminous mummia as mummy was a mistake, and physicians stopped prescribing the ineffective drug. Lastly, artists in the 17–19th centuries used ground up mummies to tint a popular oil-paint called mummy brown.

🔗 Medicine 🔗 Medicine/Neurology

Type 3 diabetes is a proposed term to describe the interlinked association between type 1 and type 2 diabetes, and Alzheimer's disease. This term is used to look into potential triggers of Alzheimer's disease in people with diabetes.

The proposed progression from diabetes to Alzheimer's disease is inadequately understood; however there are a number of hypotheses describing potential links between the two diseases. The internal mechanism of Insulin resistance and other metabolic risk factors such as hyperglycaemia, caused by oxidative stress and lipid peroxidation are common processes thought to be contributors to the development of Alzheimer's disease in diabetics.

Diagnosis for this disease is different between patients with type 1 and type 2 diabetes. Type 1 diabetes is usually discovered in children and adolescence while type 2 diabetic patients are often diagnosed later in life. While Type 3 diabetes is not a diagnosis in itself, a diagnosis of suspected Alzheimer's disease can be established through observational signs and sometimes with neuroimaging techniques such as Magnetic Resonance Imaging (MRI) to observe abnormalities in diabetic patient's brain tissue.

The techniques used to prevent the disease in patients with diabetes are similar to individuals who do not show signs of the disease. The four pillars of Alzheimer's disease prevention is currently used as a guide for individuals of whom are at risk of developing Alzheimer's disease.

Research into the effectiveness of Glucagon-like Peptide 1 and Melatonin administration to manage the progression of Alzheimer's disease in diabetic patients is currently being conducted to decrease the rate at which Alzheimer's disease progresses.

Labelling Alzheimer's disease as Type 3 Diabetes is generally controversial, and this definition is not a known medical diagnosis. While insulin resistance is a risk factor for the development of Alzheimer's disease and some other dementias, causes of Alzheimer's disease are likely to be much more complex than being explained by insulin factors on their own, and indeed several patients with Alzheimer's disease have normal insulin metabolism.