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🔗 Biography 🔗 Medicine 🔗 Women's History 🔗 Medicine/Society and Medicine

Henrietta Lacks (born Loretta Pleasant; August 1, 1920 – October 4, 1951) was an African-American woman whose cancer cells are the source of the HeLa cell line, the first immortalized human cell line and one of the most important cell lines in medical research. An immortalized cell line reproduces indefinitely under specific conditions, and the HeLa cell line continues to be a source of invaluable medical data to the present day.

Lacks was the unwitting source of these cells from a tumor biopsied during treatment for cervical cancer at Johns Hopkins Hospital in Baltimore, Maryland, U.S., in 1951. These cells were then cultured by George Otto Gey who created the cell line known as HeLa, which is still used for medical research. As was then the practice, no consent was obtained to culture her cells, nor were she or her family compensated for their extraction or use.

Lacks grew up in rural Virginia. After giving birth to two of their children, she married her cousin David "Day" Lacks. In 1941 the young family moved to Turner Station, near Dundalk, Maryland, in Baltimore County, so Day could work in Bethlehem Steel at Sparrows Point. After Lacks had given birth to their fifth child, Joseph, she was diagnosed with cancer. Tissue samples from her tumors were taken without consent during treatment and these samples were then subsequently cultured into the HeLa cell line.

Even though some information about the origins of HeLa's immortalized cell lines was known to researchers after 1970, the Lacks family was not made aware of the line's existence until 1975. With knowledge of the cell line's genetic provenance becoming public, its use for medical research and for commercial purposes continues to raise concerns about privacy and patients' rights.

🔗 United States 🔗 Computing 🔗 Television 🔗 United States/American television

Halt and Catch Fire is an American period drama television series created by Christopher Cantwell and Christopher C. Rogers. It aired on the cable network AMC in the United States from June 1, 2014, to October 14, 2017, spanning four seasons and 40 episodes. Taking place over a period of more than ten years, the series depicts a fictionalized insider's view of the personal computer revolution of the 1980s and the growth of the World Wide Web in the early 1990s. The show's title refers to computer machine code instruction Halt and Catch Fire (HCF), the execution of which would cause the computer's central processing unit to stop working (catch fire being a humorous exaggeration).

In season one, the company Cardiff Electric makes its first foray into personal computing, with entrepreneur Joe MacMillan (Lee Pace) running a project to build an IBM PC clone with the help of computer engineer Gordon Clark (Scoot McNairy) and prodigy programmer Cameron Howe (Mackenzie Davis). Seasons two and three shift focus to a startup company, the online community Mutiny, that is headed by Cameron and Gordon's wife Donna (Kerry Bishé), while Joe ventures out on his own. The fourth and final season focuses on competing web search engines involving all the principal characters.

Halt and Catch Fire marked Cantwell's and Rogers's first jobs in television. They wrote the pilot hoping to use it to secure jobs as writers in the industry but instead landed a series of their own from AMC. The story was inspired by Cantwell's childhood in the Silicon Prairie of Dallas–Fort Worth, where his father worked as a software salesman, and the creators' subsequent research into Texas's role in personal computing innovations of the 1980s. Filmed in the Atlanta, Georgia, area and produced by the network, the series is set in the Silicon Prairie for its first two seasons and Silicon Valley for its latter two.

Halt and Catch Fire debuted to generally favorable reviews, though many reviewers initially found it derivative of other series such as Mad Men. In each subsequent season, the series grew in acclaim, and by the time it concluded, critics considered it among the best shows of the 2010s. Despite its critical reception, the series experienced low viewership ratings throughout its run, with only the first episode surpassing one million viewers for its initial broadcast.

🔗 Brands 🔗 Automobiles

The Isetta is an Italian-designed microcar built under license in a number of different countries, including Argentina, Spain, Belgium, France, Brazil, Germany, and the United Kingdom. Because of its egg shape and bubble-like windows, it became known as a bubble car, a name also given to other similar vehicles.

In 1955, the BMW Isetta became the world's first mass-production car to achieve a fuel consumption of 3 L/100 km (94 mpg_‑imp; 78 mpg_‑US). It was the top-selling single-cylinder car in the world, with 161,728 units sold.

Initially manufactured by the Italian firm Iso SpA, the name Isetta is the Italian diminutive form of Iso, meaning "little Iso".

🔗 United States 🔗 Biography 🔗 Death 🔗 Criminal Biography 🔗 African diaspora 🔗 United States/South Carolina

George Junius Stinney, Jr. (October 21, 1929 – June 16, 1944), was an African American child who was convicted, in a proceeding later vacated as an unfair trial, of murdering two white girls, ages 7 and 11, in his hometown of Alcolu, South Carolina. He was executed by electric chair in June 1944. Stinney is the youngest American to be sentenced to death and executed.

A re-examination of the Stinney case began in 2004, and several individuals and Northeastern University School of Law sought a judicial review. His conviction was overturned in 2014, 70 years after he was executed when a court ruled that he had not received a fair trial.

🔗 Architecture 🔗 Materials

Foam concrete, also known as Lightweight Cellular Concrete (LCC), Low Density Cellular Concrete (LDCC), and other terms is defined as a cement-based slurry, with a minimum of 20% (per volume) foam entrained into the plastic mortar. As mostly no coarse aggregate is used for production of foam concrete the correct term would be called mortar instead of concrete; it may be called "foamed cement" as well. The density of foam concrete usually varies from 400 kg/m³ to 1600 kg/m³. The density is normally controlled by substituting fully or part of the fine aggregate with foam.

🔗 Economics 🔗 Business 🔗 International development

The O-ring theory of economic development is a model of economic development put forward by Michael Kremer in 1993, which proposes that tasks of production must be executed proficiently together in order for any of them to be of high value. The key feature of this model is positive assortative matching, whereby people with similar skill levels work together.

The name comes from the 1986 Challenger shuttle disaster, a catastrophe caused by the failure of a single O-ring.

Kremer thinks that the O-ring development theory explains why rich countries produce more complicated products, have larger firms and much higher worker productivity than poor countries.

🔗 Computing

Personal knowledge management (PKM) is a process of collecting information that a person uses to gather, classify, store, search, retrieve and share knowledge in their daily activities (Grundspenkis 2007) and the way in which these processes support work activities (Wright 2005). It is a response to the idea that knowledge workers need to be responsible for their own growth and learning (Smedley 2009). It is a bottom-up approach to knowledge management (KM) (Pollard 2008).

🔗 Novels

In the dystopian novel Nineteen Eighty-Four (1949), by George Orwell, the Two Minutes Hate is the daily, public period during which members of the Outer Party of Oceania must watch a film depicting the enemies of the state, specifically Emmanuel Goldstein and his followers, to openly and loudly express hatred for them. The political purpose of the Two Minutes Hate is to allow the citizens of Oceania to vent their existential anguish and personal hatreds towards politically expedient enemies: Goldstein and the enemy superstate of the moment. In re-directing the members' subconscious feelings away from the Party's government of Oceania, and towards non-existent external enemies, the Party minimises thoughtcrime and the consequent, subversive behaviours of thoughtcriminals.

🔗 Technology 🔗 Writing

An autopen or signing machine is a device used for the automatic signing of a signature or autograph. Many celebrities, politicians and public figures receive hundreds of letters a day, many of which request a personal reply; this leads to a situation in which either the individual must artificially reproduce their signature or heavily limit the number of recipients who receive a personal response. Given the exact verisimilitude to the real hand signature, the use of the autopen allows for a small degree of wishful thinking and plausible deniability as to whether a famous autograph is real or reproduced, thus increasing the perception of the personal value of the signature by the lay recipient. However, known or suspected autopen signatures are also vastly less valuable as philographic collectibles; legitimate hand-signed documents from individuals known to also use an autopen usually require verification and provenance to be considered valid.

The early autopens used a plastic matrix of the original signature which is a channel cut into an engraved plate in the shape of a wheel. A stylus driven by an electric motor followed the x and y axis of a profile or shape engraved in the plate (which is why it is called a matrix). The stylus is mechanically connected to an arm which can hold almost any common writing instrument, so the favourite pen and ink can be used to suggest authenticity. The Autopen signature is made with even pressure (and indentation in the paper), which is how these machines are distinguishable from original handwriting where the pressure varies.

Modern day autopens use a signature smart card or USB flash drive to store signatures and phrases instead of the plastic matrices. In addition, certain models can replicate entire pages of writing once a custom font has been created in a user's handwriting.

🔗 Environment 🔗 Agriculture 🔗 Economics 🔗 Futures studies

A Malthusian catastrophe (also known as Malthusian check, Malthusian crisis, Malthusian spectre or Malthusian crunch) occurs when population growth outpaces agricultural production.