Have a deep view into what people are curious about.

🔗 Medicine 🔗 Skepticism 🔗 Alternative medicine

Coley's toxins (also called Coley's toxin, Coley's vaccine, Coley vaccine, Coley's fluid or mixed bacterial vaccine) is a mixture consisting of killed bacteria of species Streptococcus pyogenes and Serratia marcescens, named after William Coley, a surgical oncologist at the Hospital for Special Surgery who developed the mixture in the late 19th century as a treatment for cancer.

There is no evidence that Coley's toxins have any effectiveness in treating cancer, and use of them risks causing serious harm.

🔗 Computing

Secure Scuttlebutt (SSB) is a peer-to peer communication protocol, mesh network, and self-hosted social media ecosystem. Each user hosts their own content and the content of the peers they follow, which provides fault tolerance and eventual consistency. Messages are digitally signed and added to an append-only list of messages published by an author. SSB is primarily used for implementing distributed social networks, and utilizes cryptography to assure that content remains unforged as it is propagated through the network.

🔗 Economics 🔗 Lists

This is a list of some of the major unsolved problems, puzzles, or questions in economics. Some of these are theoretical in origin and some of them concern the inability of orthodox economic theory to explain an empirical observation.

🔗 Mathematics 🔗 Economics 🔗 Game theory

A Vickrey auction or sealed-bid second-price auction (SBSPA) is a type of sealed-bid auction. Bidders submit written bids without knowing the bid of the other people in the auction. The highest bidder wins but the price paid is the second-highest bid. This type of auction is strategically similar to an English auction and gives bidders an incentive to bid their true value. The auction was first described academically by Columbia University professor William Vickrey in 1961 though it had been used by stamp collectors since 1893. In 1797 Johann Wolfgang von Goethe sold a manuscript using a sealed-bid, second-price auction.

Vickrey's original paper mainly considered auctions where only a single, indivisible good is being sold. The terms Vickrey auction and second-price sealed-bid auction are, in this case only, equivalent and used interchangeably. In the case of multiple identical goods, the bidders submit inverse demand curves and pay the opportunity cost.

Vickrey auctions are much studied in economic literature but uncommon in practice. Generalized variants of the Vickrey auction for multiunit auctions exist, such as the generalized second-price auction used in Google's and Yahoo!'s online advertisement programmes (not incentive compatible) and the Vickrey–Clarke–Groves auction (incentive compatible).

🔗 Computing 🔗 Computer Security 🔗 Computer Security/Computing

A zip bomb, also known as a zip of death or decompression bomb, is a malicious archive file designed to crash or render useless the program or system reading it. It is often employed to disable antivirus software, in order to create an opening for more traditional viruses.

Rather than hijacking the normal operation of the program, a zip bomb allows the program to work as intended, but the archive is carefully crafted so that unpacking it (e.g. by a virus scanner in order to scan for viruses) requires inordinate amounts of time, disk space or memory.

Most modern antivirus programs can detect whether a file is a zip bomb, to avoid unpacking it.

🔗 Biography 🔗 Canada 🔗 Athletics 🔗 Running 🔗 Biography/sports and games

Terrance Stanley Fox (July 28, 1958 – June 28, 1981) was a Canadian athlete, humanitarian, and cancer research activist. In 1980, with one leg having been amputated due to cancer, he embarked on an east to west cross-Canada run to raise money and awareness for cancer research. Although the spread of his cancer eventually forced him to end his quest after 143 days and 5,373 kilometres (3,339 mi), and ultimately cost him his life, his efforts resulted in a lasting, worldwide legacy. The annual Terry Fox Run, first held in 1981, has grown to involve millions of participants in over 60 countries and is now the world's largest one-day fundraiser for cancer research; over C$750 million has been raised in his name, as of January 2018.

Fox was a distance runner and basketball player for his Port Coquitlam high school, now named after him, and Simon Fraser University. His right leg was amputated in 1977 after he was diagnosed with osteosarcoma, though he continued to run using an artificial leg. He also played wheelchair basketball in Vancouver, winning three national championships.

In 1980, he began the Marathon of Hope, a cross-country run to raise money for cancer research. He hoped to raise one dollar from each of Canada's 24 million people. He began with little fanfare from St John's, Newfoundland and Labrador, in April and ran the equivalent of a full marathon every day. Fox had become a national star by the time he reached Ontario; he made numerous public appearances with businessmen, athletes, and politicians in his efforts to raise money. He was forced to end his run outside Thunder Bay when the cancer spread to his lungs. His hopes of overcoming the disease and completing his marathon ended when he died nine months later.

In addition to being the youngest person ever named a Companion of the Order of Canada, Fox won the 1980 Lou Marsh Award as the nation's top sportsman and was named Canada's Newsmaker of the Year in both 1980 and 1981. Considered a national hero, he has had many buildings, statues, roads, and parks named in his honour across the country.

🔗 Typography

An ink trap is a feature of certain typefaces designed for printing in small sizes. At an ink trap, the corners or details are removed from the letterforms. When the type is printed, ink naturally spreads into the removed area. Without ink traps, the excess ink would soak outwards and ruin the crisp edge.

Ink traps are only needed for small point sizes and are usually only found on typefaces designed for printing on newsprint. Fonts of this kind are applicable for classifieds or telephone books. Typefaces with ink traps may be offered in versions without them for display on screen or at larger sizes.

Typefaces featuring ink traps include Retina, Bell Centennial, and Tang.

🔗 International relations 🔗 Lists 🔗 Politics

This is a list of people declared persona non grata. Persona non grata (Latin, plural: personae non gratae), literally meaning "an unwelcome person", is a legal term used in diplomacy that indicates a proscription against a foreign person entering or remaining in the country. It is the most serious form of censure that one country can apply to foreign diplomats, who are otherwise protected by diplomatic immunity from arrest and other normal kinds of prosecution.

🔗 Environment 🔗 Chemicals 🔗 Animals

The M44 cyanide device (also called a cyanide gun or cyanide trap) is used for the killing of coyotes, feral dogs, and foxes. It is made from four parts: a capsule holder wrapped with cloth or other soft material, a small plastic capsule containing 0.88 grams of sodium cyanide, a spring-powered ejector, and a 5-7 inch stake. To install the trap, the stake is first driven down into the ground, and then the capsule is put in the holder, screwed onto the cocked ejector, and secured to the stake. The wrapped capsule holder is smeared with scented bait to attract coyotes and make them bite and pull on it. (The use of a bite-and-pull action makes the trap less likely to be set off by non-canine wildlife.) When the trap is triggered, the spring propels a dose of sodium cyanide into the animals's mouth, and the sodium cyanide combines with water in the mouth to produce poisonous cyanide gas. In addition to the cyanide, the capsule contains Day-Glo fluorescent particle marker (orange in capsules used by the Wildlife Services, and yellow in capsules prepared for other users).