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🔗 Human rights 🔗 Military history 🔗 Military history/North American military history 🔗 Military history/United States military history 🔗 Military history/Military science, technology, and theory 🔗 Military history/Weaponry 🔗 Medicine 🔗 Biology 🔗 Military history/World War II 🔗 Military history/Cold War 🔗 United States History 🔗 Medicine/Society and Medicine

Unethical human experimentation in the United States describes numerous experiments performed on human test subjects in the United States that have been considered unethical, and were often performed illegally, without the knowledge, consent, or informed consent of the test subjects. Such tests have occurred throughout American history, but particularly in the 20th century. The experiments include: the exposure of humans to many chemical and biological weapons (including infection with deadly or debilitating diseases), human radiation experiments, injection of toxic and radioactive chemicals, surgical experiments, interrogation and torture experiments, tests involving mind-altering substances, and a wide variety of others. Many of these tests were performed on children, the sick, and mentally disabled individuals, often under the guise of "medical treatment". In many of the studies, a large portion of the subjects were poor, racial minorities, or prisoners.

Funding for many of the experiments was provided by the United States government, especially the United States military, the Central Intelligence Agency, or private corporations involved with military activities. The human research programs were usually highly secretive, and in many cases information about them was not released until many years after the studies had been performed.

The ethical, professional, and legal implications of this in the United States medical and scientific community were quite significant, and led to many institutions and policies that attempted to ensure that future human subject research in the United States would be ethical and legal. Public outrage in the late 20th century over the discovery of government experiments on human subjects led to numerous congressional investigations and hearings, including the Church Committee and Rockefeller Commission, both of 1975, and the 1994 Advisory Committee on Human Radiation Experiments, among others.

🔗 Biology 🔗 Evolutionary biology 🔗 Tree of Life

The three-domain system is a biological classification introduced by Carl Woese et al. in 1990 that divides cellular life forms into archaea, bacteria, and eukaryote domains. In particular, it emphasizes the separation of prokaryotes into two groups, originally called Eubacteria (now Bacteria) and Archaebacteria (now Archaea). Woese argued that, on the basis of differences in 16S rRNA genes, these two groups and the eukaryotes each arose separately from an ancestor with poorly developed genetic machinery, often called a progenote. To reflect these primary lines of descent, he treated each as a domain, divided into several different kingdoms. Woese initially used the term "kingdom" to refer to the three primary phylogenic groupings, and this nomenclature was widely used until the term "domain" was adopted in 1990.

Parts of the three-domain theory have been fiercly challenged by scientists such as Radhey S. Gupta, who argues that the primary division within prokaryotes should be between those surrounded by a single membrane, and those with two membranes.

🔗 Biology 🔗 Insects 🔗 Ecology

A hyperparasite, also known as a metaparasite is a parasite whose host, often an insect, is also a parasite, often specifically a parasitoid. Hyperparasites are found mainly among the wasp-waisted Apocrita within the Hymenoptera, and in two other insect orders, the Diptera (true flies) and Coleoptera (beetles). Seventeen families in Hymenoptera and a few species of Diptera and Coleoptera are hyperparasitic. Hyperparasitism developed from primary parasitism, which evolved in the Jurassic period in the Hymenoptera. Hyperparasitism intrigues entomologists because of its multidisciplinary relationship to evolution, ecology, behavior, biological control, taxonomy, and mathematical models.

🔗 Medicine 🔗 Biology

Closed-eye hallucinations and closed-eye visualizations (CEV) are a distinct class of hallucination. These types of hallucinations generally only occur when one's eyes are closed or when one is in a darkened room. They can be a form of phosphene. Some people report closed-eye hallucinations under the influence of psychedelics. These are reportedly of a different nature than the "open-eye" hallucinations of the same compounds. Similar hallucinations that occur due to loss of vision are called visual release hallucinations.

🔗 History 🔗 Biology 🔗 Politics 🔗 Anthropology 🔗 Sociology 🔗 Conservatism 🔗 Folklore

Invented traditions are cultural practices that are presented or perceived as traditional, arising from the people starting in the distant past, but which in fact are relatively recent and often even consciously invented by identifiable historical actors. The concept was highlighted in the 1983 book The Invention of Tradition, edited by Eric Hobsbawm and Terence Ranger. Hobsbawm's introduction argues that many "traditions" which "appear or claim to be old are often quite recent in origin and sometimes invented." This "invention" is distinguished from "starting" or "initiating" a tradition that does not then claim to be old. The phenomenon is particularly clear in the modern development of the nation and of nationalism, creating a national identity promoting national unity, and legitimising certain institutions or cultural practices.

🔗 United States 🔗 Medicine 🔗 Oregon 🔗 Crime 🔗 Religion 🔗 Biology 🔗 Terrorism

The 1984 Rajneeshee bioterror attack was the food poisoning of 751 individuals in The Dalles, Oregon, through the deliberate contamination of salad bars at ten local restaurants with Salmonella. A group of prominent followers of Bhagwan Shree Rajneesh (later known as Osho) led by Ma Anand Sheela had hoped to incapacitate the voting population of the city so that their own candidates would win the 1984 Wasco County elections. The incident was the first and is the single largest bioterrorist attack in United States history.

Having previously gained political control of Antelope, Oregon, Rajneesh's followers, who were based in nearby Rajneeshpuram, sought election to two of the three seats on the Wasco County Circuit Court that were up for election in November 1984. Fearing they would not gain enough votes, some Rajneeshpuram officials decided to incapacitate voters in The Dalles, the largest population center in Wasco County. The chosen biological agent was Salmonella enterica Typhimurium, which was first delivered through glasses of water to two County Commissioners and then, on a larger scale, at salad bars and in salad dressing.

As a result of the attack, 751 people contracted salmonellosis, 45 of whom were hospitalized, but none died. Although an initial investigation by the Oregon Public Health Division and the Centers for Disease Control did not rule out deliberate contamination, the agents and contamination were only confirmed a year later. On February 28, 1985, Congressman James H. Weaver gave a speech in the United States House of Representatives in which he "accused the Rajneeshees of sprinkling Salmonella culture on salad bar ingredients in eight restaurants".

At a press conference in September 1985, Rajneesh accused several of his followers of participation in this and other crimes, including an aborted plan in 1985 to assassinate a United States Attorney, and he asked state and federal authorities to investigate. Oregon Attorney General David B. Frohnmayer set up an interagency task force, composed of Oregon State Police and the Federal Bureau of Investigation, and executed search warrants in Rajneeshpuram. A sample of bacteria matching the contaminant that had sickened the town residents was found in a Rajneeshpuram medical laboratory. Two leading Rajneeshpuram officials were convicted on charges of attempted murder and served 29 months of 20-year sentences in a minimum-security federal prison.

🔗 Biology 🔗 Molecular and Cell Biology 🔗 Genetics

DNA origami is the nanoscale folding of DNA to create non-arbitrary two- and three-dimensional shapes at the nanoscale. The specificity of the interactions between complementary base pairs make DNA a useful construction material, through design of its base sequences. DNA is a well-understood material that is suitable for creating scaffolds that hold other molecules in place or to create structures all on its own.

DNA origami was the cover story of Nature on March 16, 2006. Since then, DNA origami has progressed past an art form and has found a number of applications from drug delivery systems to uses as circuitry in plasmonic devices; however, most applications remain in a concept or testing phase.

🔗 Environment 🔗 Biology 🔗 Physics 🔗 Guild of Copy Editors 🔗 Energy 🔗 Chemical and Bio Engineering

Artificial photosynthesis is a chemical process that biomimics the natural process of photosynthesis to convert sunlight, water, and carbon dioxide into carbohydrates and oxygen. The term artificial photosynthesis is commonly used to refer to any scheme for capturing and storing the energy from sunlight in the chemical bonds of a fuel (a solar fuel). Photocatalytic water splitting converts water into hydrogen and oxygen and is a major research topic of artificial photosynthesis. Light-driven carbon dioxide reduction is another process studied that replicates natural carbon fixation.

Research of this topic includes the design and assembly of devices for the direct production of solar fuels, photoelectrochemistry and its application in fuel cells, and the engineering of enzymes and photoautotrophic microorganisms for microbial biofuel and biohydrogen production from sunlight.

🔗 Biology 🔗 Women's History 🔗 Anthropology 🔗 Human Genetic History 🔗 Molecular Biology 🔗 Molecular Biology/Molecular and Cell Biology 🔗 Molecular Biology/Genetics

In human genetics, the Mitochondrial Eve (more technically known as the Mitochondrial-Most Recent Common Ancestor, shortened to mt-Eve or mt-MRCA) is the matrilineal most recent common ancestor (MRCA) of all living humans. In other words, she is defined as the most recent woman from whom all living humans descend in an unbroken line purely through their mothers and through the mothers of those mothers, back until all lines converge on one woman.

In terms of mitochondrial haplogroups, the mt-MRCA is situated at the divergence of macro-haplogroup L into L0 and L1–6. As of 2013, estimates on the age of this split ranged at around 155,000 years ago, consistent with a date later than the speciation of Homo sapiens but earlier than the recent out-of-Africa dispersal.

The male analog to the "Mitochondrial Eve" is the "Y-chromosomal Adam" (or Y-MRCA), the individual from whom all living humans are patrilineally descended. As the identity of both matrilineal and patrilineal MRCAs is dependent on genealogical history (pedigree collapse), they need not have lived at the same time. As of 2015, estimates of the age of the Y-MRCA range around 200,000 to 300,000 years ago, roughly consistent with the emergence of anatomically modern humans.

The name "Mitochondrial Eve" alludes to the biblical Eve, which has led to repeated misrepresentations or misconceptions in journalistic accounts on the topic. Popular science presentations of the topic usually point out such possible misconceptions by emphasizing the fact that the position of mt-MRCA is neither fixed in time (as the position of mt-MRCA moves forward in time as mitochondrial DNA (mtDNA) lineages become extinct), nor does it refer to a "first woman", nor the only living female of her time, nor the first member of a "new species".

🔗 Medicine 🔗 Biology 🔗 Skepticism 🔗 Transhumanism 🔗 Alternative Views 🔗 Guild of Copy Editors 🔗 Alternative medicine 🔗 Longevity

Life extension is the idea of extending the human lifespan, either modestly – through improvements in medicine – or dramatically by increasing the maximum lifespan beyond its generally settled limit of 125 years. The ability to achieve such dramatic changes, however, does not currently exist.

Some researchers in this area, and "life extensionists", "immortalists" or "longevists" (those who wish to achieve longer lives themselves), believe that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition. The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists.

The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that promotes the use of hormones as a treatment for consumers to slow or reverse the aging process in the US market generated about $50 billion of revenue a year in 2009. The use of such products has not been proven to be effective or safe.