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🔗 Technology 🔗 Physics 🔗 Neuroscience 🔗 Molecular Biology 🔗 Molecular Biology/Molecular and Cell Biology

Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser scanning confocal microscopy (LSCM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a spatial pinhole to block out-of-focus light in image formation. Capturing multiple two-dimensional images at different depths in a sample enables the reconstruction of three-dimensional structures (a process known as optical sectioning) within an object. This technique is used extensively in the scientific and industrial communities and typical applications are in life sciences, semiconductor inspection and materials science.

Light travels through the sample under a conventional microscope as far into the specimen as it can penetrate, while a confocal microscope only focuses a smaller beam of light at one narrow depth level at a time. The CLSM achieves a controlled and highly limited depth of field.

🔗 Neuroscience

The frequency format hypothesis is the idea that the brain understands and processes information better when presented in frequency formats rather than a numerical or probability format. Thus according to the hypothesis, presenting information as 1 in 5 people rather than 20% leads to better comprehension. The idea was proposed by German scientist Gerd Gigerenzer, after compilation and comparison of data collected between 1976–1997.

🔗 Medicine 🔗 Viruses 🔗 Dogs 🔗 Cats 🔗 Neuroscience 🔗 Microbiology 🔗 Medicine/Neurology 🔗 Rodents 🔗 Medicine/Translation 🔗 Veterinary medicine 🔗 Medicine/Dermatology

Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: violent movements, uncontrolled excitement, fear of water, an inability to move parts of the body, confusion, and loss of consciousness. Once symptoms appear, the result is nearly always death. The time period between contracting the disease and the start of symptoms is usually one to three months, but can vary from less than one week to more than one year. The time depends on the distance the virus must travel along peripheral nerves to reach the central nervous system.

Rabies is caused by lyssaviruses, including the rabies virus and Australian bat lyssavirus. It is spread when an infected animal bites or scratches a human or other animal. Saliva from an infected animal can also transmit rabies if the saliva comes into contact with the eyes, mouth, or nose. Globally, dogs are the most common animal involved. In countries where dogs commonly have the disease, more than 99% of rabies cases are the direct result of dog bites. In the Americas, bat bites are the most common source of rabies infections in humans, and less than 5% of cases are from dogs. Rodents are very rarely infected with rabies. The disease can be diagnosed only after the start of symptoms.

Animal control and vaccination programs have decreased the risk of rabies from dogs in a number of regions of the world. Immunizing people before they are exposed is recommended for those at high risk, including those who work with bats or who spend prolonged periods in areas of the world where rabies is common. In people who have been exposed to rabies, the rabies vaccine and sometimes rabies immunoglobulin are effective in preventing the disease if the person receives the treatment before the start of rabies symptoms. Washing bites and scratches for 15 minutes with soap and water, povidone-iodine, or detergent may reduce the number of viral particles and may be somewhat effective at preventing transmission. As of 2016, only fourteen people had survived a rabies infection after showing symptoms.

Rabies caused about 17,400 human deaths worldwide in 2015. More than 95% of human deaths from rabies occur in Africa and Asia. About 40% of deaths occur in children under the age of 15. Rabies is present in more than 150 countries and on all continents but Antarctica. More than 3 billion people live in regions of the world where rabies occurs. A number of countries, including Australia and Japan, as well as much of Western Europe, do not have rabies among dogs. Many Pacific islands do not have rabies at all. It is classified as a neglected tropical disease.

🔗 Medicine 🔗 Transhumanism 🔗 Neuroscience 🔗 Pharmacology 🔗 Psychoactive and Recreational Drugs

Modafinil, sold under the brand name Provigil among others, is a medication to treat sleepiness due to narcolepsy, shift work sleep disorder, or obstructive sleep apnea. While it has seen off-label use as a purported cognitive enhancer, the research on its effectiveness for this use is not conclusive. It is taken by mouth.

Common side effects include headache, anxiety, trouble sleeping, and nausea. Serious side effects may include allergic reactions such as anaphylaxis, Stevens–Johnson syndrome, misuse, and hallucinations. It is unclear if use during pregnancy is safe. The amount of medication used may need to be adjusted in those with kidney or liver problems. It is not recommended in those with an arrhythmia, significant hypertension, or left ventricular hypertrophy. How it works is not entirely clear. One possibility is that it may affect the areas of the brain involved with the sleep cycle.

Modafinil was approved for medical use in the United States in 1998. In the United States it is classified as a schedule IV controlled substance. In the United Kingdom it is a prescription only medication. It is available as a generic medication. In the United Kingdom it costs the NHS about £105.21 a month as of 2018. In the United States the wholesale cost per month is about US$34.20 as of 2018. In 2016, it was the 284th most prescribed medication in the United States, with more than a million prescriptions.

🔗 Internet culture 🔗 Medicine 🔗 Psychology 🔗 Electronic music 🔗 Neuroscience 🔗 Medicine/Neurology 🔗 Medicine/Society and Medicine 🔗 Albums

Everywhere at the End of Time is the eleventh recording by the Caretaker, an alias of English electronic musician Leyland Kirby. Released between 2016 and 2019, its six studio albums use degrading loops of sampled ballroom music to portray the progression of Alzheimer's disease. Inspired by the success of An Empty Bliss Beyond This World (2011), Kirby produced Everywhere as his final major work under the alias. The albums were produced in Krakow and released over six-month periods to "give a sense of time passing". The album covers are abstract paintings by his friend Ivan Seal. The series drew comparisons to the works of composer William Basinski and electronic musician Burial; later stages were influenced by avant-gardist composer John Cage.

The series comprises six hours of music, portraying a range of emotions and characterised by noise throughout. Although the first three stages are similar to An Empty Bliss, the last three stages depart from Kirby's earlier ambient works. The albums reflect the patient's disorder and death, their feelings, and the phenomenon of terminal lucidity. To promote the series, Kirby partnered with anonymous visual artist Weirdcore to make music videos. At first, concerned about whether the series would seem pretentious, Kirby thought of not creating Everywhere at all; he spent more time producing it than any of his other releases. The album covers received attention from a French art exhibition named after the Caretaker's Everywhere, an Empty Bliss (2019), a compilation of archived songs.

As each stage was released, the series received increasingly positive reviews from critics; its length and dementia-driven concept led many reviewers to feel emotional about the complete edition. Considered to be Kirby's magnum opus, Everywhere was one of the most praised music releases of the 2010s. Caregivers of people with dementia also praised the albums for increasing empathy for patients among younger listeners, although some medics felt the series was too linear. It became an Internet phenomenon in the early 2020s, emerging in TikTok videos as a listening challenge, being transformed into a mod for the video game Friday Night Funkin' (2020), and appearing in internet memes.

🔗 Philosophy 🔗 Cognitive science 🔗 Linguistics 🔗 Linguistics/Applied Linguistics 🔗 Anthropology 🔗 Philosophy/Philosophy of mind 🔗 Neuroscience 🔗 Philosophy/Philosophy of language 🔗 Linguistics/Philosophy of language

The hypothesis of linguistic relativity, part of relativism, also known as the Sapir–Whorf hypothesis , or Whorfianism is a principle claiming that the structure of a language affects its speakers' world view or cognition, and thus people's perceptions are relative to their spoken language.

The principle is often defined in one of two versions: the strong hypothesis, which was held by some of the early linguists before World War II, and the weak hypothesis, mostly held by some of the modern linguists.

• The strong version says that language determines thought and that linguistic categories limit and determine cognitive categories.
• The weak version says that linguistic categories and usage only influence thought and decisions.

The principle had been accepted and then abandoned by linguists during the early 20th century following the changing perceptions of social acceptance for the other especially after World War II. The origin of formulated arguments against the acceptance of linguistic relativity are attributed to Noam Chomsky.

🔗 Cognitive science 🔗 Neuroscience

Sparse distributed memory (SDM) is a mathematical model of human long-term memory introduced by Pentti Kanerva in 1988 while he was at NASA Ames Research Center. It is a generalized random-access memory (RAM) for long (e.g., 1,000 bit) binary words. These words serve as both addresses to and data for the memory. The main attribute of the memory is sensitivity to similarity, meaning that a word can be read back not only by giving the original write address but also by giving one close to it, as measured by the number of mismatched bits (i.e., the Hamming distance between memory addresses).

SDM implements transformation from logical space to physical space using distributed data representation and storage, similarly to encoding processes in human memory. A value corresponding to a logical address is stored into many physical addresses. This way of storing is robust and not deterministic. A memory cell is not addressed directly. If input data (logical addresses) are partially damaged at all, we can still get correct output data.

The theory of the memory is mathematically complete and has been verified by computer simulation. It arose from the observation that the distances between points of a high-dimensional space resemble the proximity relations between concepts in human memory. The theory is also practical in that memories based on it can be implemented with conventional RAM-memory elements.

🔗 Animal anatomy 🔗 Neuroscience 🔗 Anatomy 🔗 Anatomy/Neuroanatomy

The enteric nervous system (ENS) or intrinsic nervous system is one of the main divisions of the autonomic nervous system (ANS) and consists of a mesh-like system of neurons that governs the function of the gastrointestinal tract. It is capable of acting independently of the sympathetic and parasympathetic nervous systems, although it may be influenced by them. The ENS is also called the second brain.It is derived from neural crest cells.

The enteric nervous system is capable of operating independently of the brain and spinal cord, but does rely on innervation from the autonomic nervous system via the vagus nerve and prevertebral ganglia in healthy subjects. However, studies have shown that the system is operable with a severed vagus nerve. The neurons of the enteric nervous system control the motor functions of the system, in addition to the secretion of gastrointestinal enzymes. These neurons communicate through many neurotransmitters similar to the CNS, including acetylcholine, dopamine, and serotonin. The large presence of serotonin and dopamine in the gut are key areas of research for neurogastroenterologists.

🔗 Biology 🔗 Politics 🔗 Psychology 🔗 Neuroscience 🔗 Genetics 🔗 Physiology 🔗 Physiology/neuro 🔗 Evolutionary biology 🔗 Conservatism

A number of studies have found that biology can be linked with political orientation. This means that biology is a possible factor in political orientation but may also mean that the ideology a person identifies with changes a person's ability to perform certain tasks. Many of the studies linking biology to politics remain controversial and unreplicated, although the overall body of evidence is growing.

🔗 Biology 🔗 Neuroscience 🔗 Physiology 🔗 Science

A microtome (from the Greek mikros, meaning "small", and temnein, meaning "to cut") is a cutting tool used to produce extremely thin slices of material known as sections, with the process being termed microsectioning. Important in science, microtomes are used in microscopy for the preparation of samples for observation under transmitted light or electron radiation.

Microtomes use steel, glass or diamond blades depending upon the specimen being sliced and the desired thickness of the sections being cut. Steel blades are used to prepare histological sections of animal or plant tissues for light microscopy. Glass knives are used to slice sections for light microscopy and to slice very thin sections for electron microscopy. Industrial grade diamond knives are used to slice hard materials such as bone, teeth and tough plant matter for both light microscopy and for electron microscopy. Gem-quality diamond knives are also used for slicing thin sections for electron microscopy.

Microtomy is a method for the preparation of thin sections for materials such as bones, minerals and teeth, and an alternative to electropolishing and ion milling. Microtome sections can be made thin enough to section a human hair across its breadth, with section thickness between 50 nm and 100 μm.